Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI
| Autor: | Minerva Becker, Nicolas Balagué, Denis Salomon, Laurence Toutous-Trellu, Xavier Montet, Alexandra Calmy |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Injections Subcutaneous Human immunodeficiency virus (HIV) Dermatology Facial lipoatrophy Cosmetic Techniques medicine.disease_cause ddc:616.0757 Skin thickness chemistry.chemical_compound Dermal Fillers Hyaluronic acid medicine Humans Tissue Distribution Tissue distribution Prospective Studies Hyaluronic Acid ddc:612 Skin ddc:616 medicine.diagnostic_test business.industry HIV-Associated Lipodystrophy Syndrome Water Magnetic resonance imaging Middle Aged Magnetic Resonance Imaging chemistry Adipose Tissue Face Quality of Life Atrophy Water binding business Nuclear medicine |
| Zdroj: | Dermatology, Vol. 230, No 4 (2015) pp. 367-374 |
| ISSN: | 1421-9832 1018-8665 |
| Popis: | Objective: This prospective observational study evaluated magnetic resonance imaging (MRI) findings of hyaluronic acid (HA) injections used for the correction of HIV-associated facial lipoatrophy. Methods: Ten consecutive males underwent subdermal HA injection (mean 1.3 ± 0.6 ml per side) and MRI examinations prior to and then 1, 6 and 12 months after injection. Two radiologists blinded to the clinical data assessed morphologic and quantitative changes. Results: MRI revealed HA deposition in the subdermal and deep fat compartments. A significant HA volume increase was observed 1 month after injection (mean increase 331%, p < 0.0001) as compared to the injected amount. No volume reduction occurred at 12 months (p = 0.9961). The measured bound water content did not change (p > 0.9991), whereas skin thickness and tissue vascularization increased during the first 6 months (p = 0.01). Conclusion: Our data show that the cosmetic results of HA injections are caused by water binding in the deep facial fat and by a transient increase in vascularization and skin thickness. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|