Feline Thyroid Adenomas are in Part Associated with Mutations in the Gsα Gene and not with Polymorphisms Found in the Thyrotropin Receptor
| Autor: | Peeters Me, Jan A. Mol, Elpetra P. M. Timmermans-Sprang |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adenoma
endocrine system endocrine system diseases Endocrinology Diabetes and Metabolism DNA Mutational Analysis Molecular Sequence Data Gene mutation Biology Hyperthyroidism Thyrotropin receptor Endocrinology Reference Values GTP-Binding Protein alpha Subunits Gs Extracellular Animals Euthyroid Amino Acid Sequence Thyroid Neoplasms Codon Receptor Gene Genetics Polymorphism Genetic CATS Base Sequence Receptors Thyrotropin eye diseases Transmembrane protein Protein Structure Tertiary Cats hormones hormone substitutes and hormone antagonists |
| Zdroj: | Thyroid. 12:571-575 |
| ISSN: | 1557-9077 1050-7256 |
| Popis: | The etiopathogenesis of feline thyrotoxicosis is unknown. The transmembrane part (gene codons 480-640) of the thyrotropin receptor (TSHR) gene of hyperthyroid cats has already been investigated for the presence of stimulating mutations. No mutations were found in this part of the TSHR gene. We have investigated the TSHR gene codons 66-530 for gene mutations in 10 hyperthyroid cats and in 1 euthyroid cat. This part of the TSHR gene encodes the transmembrane part as well as most of the extracellular part of the receptor. The G(s alpha) gene of these cats was also sequenced and subjected to mutational analysis. Although our study revealed a polymorphism in the TSHR gene, no association was found with tumor formation. In 4 of 10 cats with hyperthyroidism a G(s alpha) gene mutation was found. This work suggests that mutations in the extracellular or transmembrane part of the TSHR gene are not likely the cause of feline hyperthyroidism. Mutations in the G(s alpha) gene, however, may play a role in the etiopathogenesis of this disease. |
| Databáze: | OpenAIRE |
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