Trend of Drug-Resistant HIV Type 1 Emergence among Therapy-Naive Patients in Nagoya, Japan: An 8-Year Surveillance from 1999 to 2006
| Autor: | Naoto Mamiya, Saeko Fujisaki, Yoshiyuki Yokomaku, Kazuyo Nakamura, Junko Hattori, Shiro Ibe, Motohiro Hamaguchi, Urara Shigemi, Tsuguhiro Kaneda, Takejiro Kazumi, Kayoko Shimizu, Seiichiro Fujisaki |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Genotype Molecular Sequence Data Immunology HIV Infections Drug resistance medicine.disease_cause Virus Nucleoside Reverse Transcriptase Inhibitor HIV Protease Japan Virology Drug Resistance Viral Prevalence medicine Humans Phylogeny Genetics Mutation Reverse-transcriptase inhibitor biology virus diseases Sequence Analysis DNA biology.organism_classification HIV Reverse Transcriptase Reverse transcriptase Infectious Diseases Population Surveillance Lentivirus HIV-1 Female medicine.drug |
| Zdroj: | AIDS Research and Human Retroviruses. 24:7-14 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2007.0129 |
| Popis: | We studied the emergence of drug-resistant human immunodeficiency virus type 1 (HIV-1) with major amino acid mutations in 402 therapy-naive patients at Nagoya Medical Center, Japan, between 1999 and 2006. The mean prevalence of drug-resistant HIV-1 was 6.7% (range, 2.3-10.0%; n = 27). HIV-1 variants with protease inhibitor (PI)-resistant mutations alone were most frequently found (3.5%, n = 14), followed by those with nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant mutations alone (1.7%, n = 7). Variants with nucleoside reverse transcriptase inhibitor (NRTI)-resistant mutations alone were sporadically found (1.0%, n = 4). A variant possessing both NRTI- and PI-resistant mutations was detected in one patient (0.2%) and a variant possessing both NNRTI- and PI-resistant mutations was identified in another patient (0.2%). In addition, another 17 variants (4.2%, n = 17) with only 215-revertant mutations (T215C/D/G/L/S) that can easily reconvert to the nucleoside analogue-associated mutation of T215Y/F were found. The 402 viruses were phylogenetically analyzed, revealing three independent clusters comprising PI-resistant variants with the M46I or L90M mutation, NNRTI-resistant variants with the K103N mutation, and 215-revertant variants. The PI-resistant and 215-revertant strains have been spreading since 2000, and the NNRTI-resistant strain has started spreading since 2003. The nature of the epidemic and information for successfully blocking the spread of drug-resistant HIV-1 were clarified in this study. |
| Databáze: | OpenAIRE |
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