Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells
| Autor: | Ling Wu, Qianru Wei, Joanna Brzostek, Nicholas R. J. Gascoigne |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunological Synapses T-Lymphocytes T cell Immunology Receptors Antigen T-Cell Review Article Biology Lymphocyte Activation Immunological synapse 03 medical and health sciences 0302 clinical medicine Antigen medicine Animals Humans Immunology and Allergy Receptor Receptors Chimeric Antigen Immunological synapse formation T-cell receptor Chimeric antigen receptor Cell biology 030104 developmental biology Infectious Diseases medicine.anatomical_structure Signal transduction Signal Transduction 030215 immunology |
| Zdroj: | Cell Mol Immunol |
| ISSN: | 2042-0226 1672-7681 |
| DOI: | 10.1038/s41423-020-0470-3 |
| Popis: | T cells react to foreign or self-antigens through T cell receptor (TCR) signaling. Several decades of research have delineated the mechanism of TCR signal transduction and its impact on T cell performance. This knowledge provides the foundation for chimeric antigen receptor T cell (CAR-T cell) technology, by which T cells are redirected in a major histocompatibility complex-unrestricted manner. TCR and CAR signaling plays a critical role in determining the T cell state, including exhaustion and memory. Given its artificial nature, CARs might affect or rewire signaling differently than TCRs. A better understanding of CAR signal transduction would greatly facilitate improvements to CAR-T cell technology and advance its usefulness in clinical practice. Herein, we systematically review the knowns and unknowns of TCR and CAR signaling, from the contact of receptors and antigens, proximal signaling, immunological synapse formation, and late signaling outcomes. Signaling through different T cell subtypes and how signaling is translated into practice are also discussed. |
| Databáze: | OpenAIRE |
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