Partial immunoparesis contributes to risk of early infections in patients with multiple myeloma

Autor:	Weimin Huang, Yongqiang Wei, Qi Wei, Ru Feng, Xiaolei Wei
Rok vydání:	2021
Předmět:	Oncology Cancer Research medicine.medical_specialty business.industry prediction Immunoparesis medicine.disease infection Internal medicine medicine Original Article Radiology Nuclear Medicine and imaging In patient multiple myeloma (MM) business Multiple myeloma
Zdroj:	Translational Cancer Research
ISSN:	2219-6803 2218-676X
DOI:	10.21037/tcr-21-1627
Popis:	Background Partial immunoparesis, which means at least two suppressed uninvolved immunoglobulins (Igs), had been reported to be associated with poor prognosis in patients with multiple myeloma (MM), but the impact on early infections remains unknown. The purpose of our study was to determine the prognostic implications of partial immunoparesis on early grade ≥3 infections in patients with MM. Methods Herein we retrospectively analyzed the clinical data of 123 MM patients between 2012 and 2020 at Nanfang Hospital. All patients received bortezomib-based regimens. The relationship between early grade ≥3 infections and partial immunoparesis was investigated using Cox regression analysis. Results Our data showed partial immunoapresis was found in 63% MM patients. Partial immunoparesis was significantly related to elevated beta-2-microglobulin (B2M), decreased estimated glomerular filtration rate (eGFR) and progressive international staging system (ISS) stage (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19d8b8cffb65a71d82b6c7ccc62d319 https://doi.org/10.21037/tcr-21-1627 Zobrazit plný text záznamu