Patterns of neuropsychological impairment in frontotemporal dementia
| Autor: | Peachie Moore, Shweta Antani, David J. Libon, Sharon X. Xie, Murray Grossman, Katy Cross, Jennifer M. Farmer, G. McCawley |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Semantic dementia Audiology Neuropsychological Tests Sensitivity and Specificity Diagnosis Differential Progressive nonfluent aphasia Alzheimer Disease medicine Corticobasal degeneration Semantic memory Humans Diagnosis Computer-Assisted Psychiatry Aged Working memory Neuropsychology Reproducibility of Results Middle Aged medicine.disease Dementia Female Neurology (clinical) Alzheimer's disease Psychomotor Disorders Psychology Cognition Disorders Algorithms Psychomotor Performance Frontotemporal dementia |
| Zdroj: | Neurology. 68(5) |
| ISSN: | 1526-632X |
| Popis: | Objective: To differentiate frontotemporal dementia (FTD) subtypes from each other and from probable Alzheimer disease (AD) using neuropsychological tests. Methods: Patients with FTD and AD (n = 109) were studied with a comprehensive neuropsychological protocol at first contact. Data were subjected to a principal components analysis (PCA) to extract core neuropsychological features. A five-factor solution accounted for 72.89% of the variance and yielded factors related to declarative memory, working memory/visuoconstruction, processing speed/mental flexibility, lexical retrieval, and semantic memory. Results: Between- and within-group analyses revealed that patients with AD obtain their lowest scores on tests of declarative memory while semantic dementia (SemD) patients are particularly disadvantaged on tests of semantic memory. On tests of processing speed/mental flexibility time to completion was faster for social comportment/dysexecutive (SOC/EXEC) patients, but these patients made more errors on some tests. Patients with corticobasal degeneration (CBD) and progressive nonfluent aphasia (PNFA) were impaired on tests of working memory. Logistic regression analyses using factor scores successfully assigned FTD subgroups and AD patients into their respective diagnostic categories. Conclusion: Patients with differing frontotemporal dementia phenotypes can be distinguished from each other and from Alzheimer disease using neuropsychological tests. |
| Databáze: | OpenAIRE |
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