Glycosylated Hemoglobin as a Predictor of Fetal Pulmonic Maturity in Insulin-Dependent Diabetes at Term
| Autor: | Kerry M. Lewis, Alessandro Ghidini, Catherine Y. Spong, Caroline M. Heimberger |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Amniotic fluid endocrine system diseases Birth weight Pregnancy in Diabetics Fetal Organ Maturity Pregnancy Internal medicine medicine Humans Prospective Studies Lung Glycemic Glycated Hemoglobin Fetus medicine.diagnostic_test business.industry nutritional and metabolic diseases Obstetrics and Gynecology Phosphatidylglycerols Amniotic Fluid medicine.disease Diabetes Mellitus Type 1 Endocrinology Pediatrics Perinatology and Child Health Amniocentesis Gestation Female Hemoglobin business |
| Zdroj: | American Journal of Perinatology. 16:257-260 |
| ISSN: | 1098-8785 0735-1631 |
| Popis: | In insulin dependent diabetic (IDDM) gestations, fetal pulmonary maturity is delayed in the presence of suboptimal glycemic control. Serum glycosylated hemoglobin (HbA1c) provides a means of assessing glycemic control. We evaluated maternal HbA1 c in IDDM pregnancies at term undergoing amniocentesis for lung maturity to establish if euglycemia is associated with improved fetal lung maturity. Between July 1995 and June 1996, IDDM patients undergoing amniocentesis at term for lung maturity studies had a maternal serum sample analyzed for HbA1c. Fetal lung maturity was established by the presence of phosphatidylglycerol (PG) in amniotic fluid. HbA1c was considered elevated if >6.2%. Mean HbA1 c level was 6.8% (range 4.4 to 9.9%). PG was present in 54% of patients with elevated HbA1c (7/13) versus 80% of those with normal HbA1 c (8/10) (p = 0.4). Although birth weight was higher in the elevated than in the normal HbA1c group (3770 ± 514 vs. 3215 ± 610 g), no association was present between birth weight and HbA1 c level (r = 0.22, p = 0.4). The rate of a mature pulmonic profile at term is not significantly different between IDDM women with good or poor glycemic control. HbA1 c values should not be used to predict the presence or absence of amniotic fluid PG. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|