The Epithelial-Mesenchymal Transition Initiated by Malignant Ascites Underlies the Transmesothelial Invasion of Ovarian Cancer Cells
| Autor: | Rafał Moszyński, Justyna Mikuła-Pietrasik, Krzysztof Książek, Paweł Uruski, Katarzyna Kostka-Jeziorny, Stefan Sajdak, Anna Witucka, Eryk Naumowicz, Andrzej Tykarski, Martyna Pakuła |
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| Rok vydání: | 2018 |
| Předmět: |
Epithelial-Mesenchymal Transition
endocrine system diseases Cell Catalysis Article Inorganic Chemistry lcsh:Chemistry Peritoneal cavity Cell Movement Cell Line Tumor Ascites Medicine Humans Neoplasm Invasiveness Epithelial–mesenchymal transition Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Cells Cultured Ovarian Neoplasms business.industry Organic Chemistry malignant ascites General Medicine medicine.disease female genital diseases and pregnancy complications Computer Science Applications medicine.anatomical_structure ovarian cancer lcsh:Biology (General) lcsh:QD1-999 Cell culture Cancer cell Cancer research Female Signal transduction medicine.symptom business Ovarian cancer Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 20, Iss 1, p 137 (2019) Volume 20 Issue 1 |
| ISSN: | 1422-0067 |
| Popis: | The role of the epithelial-mesenchymal transition (EMT) in ovarian cancer cell progression is unquestioned. In this report, we describe that malignant ascites, fluid that accumulates in the peritoneal cavity in a large group of patients with ovarian cancer, stimulate EMT in two representative ovarian cancer cell lines (A2780, SKOV-3). In addition, we identify the ascites-derived mediators of EMT and signaling pathways initiated in the cancer cells that underlie this phenomenon. Finally, we demonstrate that EMT induced in the cancer cells in response to the malignant ascites contributes to their increased transmesothelial invasion. Altogether, our study provides new insight into the mechanistic aspects of the malignant ascites-dependent exacerbation of the intraperitoneal progression of ovarian cancer. |
| Databáze: | OpenAIRE |
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