The combined use of tocilizumab and hemoadsorption in a patient with SARS-COV-2-19-associated pneumonia: A case report
| Autor: | Giorgio Berlot, Ugo Gerini, Fabrizio Chiella, Ariella Tomasini, Francesco Bianco, Anna Randino, Marco Piva, Cristina La Fata, Erik Roman Pognuz, Tommaso Trenti, Vittorio Di Maso, Paola Amato, Paola Tomietto |
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| Přispěvatelé: | Berlot, G., Tomasini, A., Pognuz, E. R., Randino, A., Chiella, F., La Fata, C., Piva, M., Amato, P., Di Maso, V., Bianco, F., Gerini, U., Tomietto, P., Trenti, T. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
ARDS SARS-COV-2-19 medicine.medical_treatment 030232 urology & nephrology Interleukin 6 030204 cardiovascular system & hematology Gastroenterology chemistry.chemical_compound 0302 clinical medicine Monoclonal Medicine Viral Respiratory system Humanized biology Tocilizumab Combined Modality Therapy medicine.anatomical_structure Coronavirus Infections Human Adult medicine.medical_specialty Pneumonia Viral Antibodies Monoclonal Humanized Antibodies Proinflammatory cytokine C-reactive protein CytoSorb C-Reactive Protein COVID-19 Hemofiltration Humans Interleukin-6 Pandemics SARS-CoV-2 Sorption Detoxification Betacoronavirus 03 medical and health sciences Internal medicine Clinical Practice: Case Report Lung Pandemic business.industry Coronavirus Infection Pneumonia medicine.disease chemistry biology.protein business |
| Zdroj: | Nephron. Clinical Practice |
| Popis: | The SARS-COV-2-19-associated respiratory involvement is caused by the massive release of inflammatory cytokines ultimately leading to interstitial pneumonia and acute respiratory distress syndrome (ARDS). In the absence of an effective antiviral treatment, a reasonable causal approach could be constituted by the neutralization of these substances. The authors describe the clinical course of a patient with SARS-COV-2-19 interstitial pneumonia treated with the combination of an anti-interleukin 6 (IL-6) agent (tocilizumab) and hemoadsorption (HA). This combination was used to abate the surge of inflammatory mediators leading to the lung damage. Blood levels of IL-6 and C-reactive protein (CRP) were measured before the initiation of the treatment and in the following 3 days. At the end of the treatment, the values of IL-6 and CRP decreased from 1,040 to 415 pg/mL and from 229 to 59 mg/L, respectively. The gas exchanges and the chest imaging rapidly improved, and the patient was extubated 10 days later. The combination of tocilizumab and HA could be valuable in the treatment of SARS-COV-2-19-associated pneumonia and ARDS that are caused by the release of inflammatory mediators. |
| Databáze: | OpenAIRE |
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