Psychoneuroimmunology and immunopsychiatry of zebrafish
| Autor: | Allan V. Kalueff, Rodrigo Zanandrea, Murilo S. de Abreu, Bruna E. dos Santos, Ana C.V.V. Giacomini, Gabriel G. de Oliveira, Ashton J. Friend, Rafael Genario, Tamara G. Amstislavskaya |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
animal structures Endocrinology Diabetes and Metabolism ved/biology.organism_classification_rank.species Gut–brain axis Danio Translational Research Biomedical 03 medical and health sciences Endocrinology Immune system Immunopsychiatry Animals Humans Model organism Zebrafish Biological Psychiatry Toll-like receptor Brain Diseases biology Endocrine and Autonomic Systems ved/biology Mental Disorders Brain Psychoneuroimmunology biology.organism_classification Psychiatry and Mental health Disease Models Animal 030104 developmental biology Neuroscience |
| Zdroj: | Psychoneuroendocrinology. 92 |
| ISSN: | 1873-3360 |
| Popis: | Despite the high prevalence of neural and immune disorders, their etiology and molecular mechanisms remain poorly understood. As the zebrafish ( Danio rerio ) is increasingly utilized as a powerful model organism in biomedical research, mounting evidence suggests these fish as a useful tool to study neural and immune mechanisms and their interplay. Here, we discuss zebrafish neuro-immune mechanisms and their pharmacological and genetic modulation, the effect of stress on cytokines, as well as relevant models of microbiota-brain interplay. As many human brain diseases are based on complex interplay between the neural and the immune system, here we discuss zebrafish models, as well as recent successes and challenges, in this rapidly expanding field. We particularly emphasize the growing utility of zebrafish models in translational immunopsychiatry research, as they improve our understanding of pathogenetic neuro-immune interactions, thereby fostering future discovery of potential therapeutic agents. |
| Databáze: | OpenAIRE |
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