Postoperative Radiation Therapy in Patients with Extracranial Chondrosarcoma: A Joint Study of the French Sarcoma Group and Rare Cancer Network
| Autor: | Ange Mampuya, Julia Salleron, Cécile Le Péchoux, Marco Krengli, Thomas Zilli, Paul Sargos, Sébastien Salas, Mahmut Ozsahin, Marie Pierre Sunyach, Florian Baumard, Myroslav Lutsyk, Berardino De Bari, Guillaume Vogin, Juliette Thariat, Justine Attal, Anne Gomez-Brouchet, Vardouhie Karahissarlian, M. Terlizzi, Goulven Rochcongar, Felipe A. Calvo, C. Solé, Delphine Lerouge, Céline Bazille, Etienne Rapeaud, Vincent Roth |
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| Přispěvatelé: | Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Chondrosarcoma Bone Neoplasms mesenchymal bone survival ddc:616.0757 030218 nuclear medicine & medical imaging surgery 03 medical and health sciences 0302 clinical medicine Port (medical) adjuvant medicine postoperative Humans Radiology Nuclear Medicine and imaging Postoperative Period radiotherapy Retrospective Studies [PHYS]Physics [physics] Radiation business.industry chondrosarcoma myxoid radioresistance soft tissue Standard treatment Incidence (epidemiology) Hazard ratio Retrospective cohort study Middle Aged medicine.disease Prognosis Confidence interval 3. Good health Treatment Outcome Oncology 030220 oncology & carcinogenesis Female Radiology Sarcoma France business |
| Zdroj: | International Journal of Radiation Oncology Biology Physics International Journal of Radiation Oncology Biology Physics, 2020, 107 (4), pp.726-735. ⟨10.1016/j.ijrobp.2020.03.041⟩ International Journal of Radiation Oncology, Biology, Physics, Vol. 107, No 4 (2020) pp. 726-735 |
| ISSN: | 0360-3016 |
| Popis: | International audience; PurposePostoperative radiation therapy (poRT) of intracranial/skull base chondrosarcomas (CHSs) is standard treatment. However, consensus is lacking for poRT in extracranial CHS (eCHS) owing to their easier resectability and intrinsic radioresistance. We assessed the practice and efficacy of poRT in eCHS.Methods and MaterialsThis multicentric retrospective study of the French Sarcoma Group/Rare Cancer Network included patients with eCHS who were operated on between 1985 and 2015. Inverse propensity score weighting (IPTW) was used to minimize poRT allocation biases.ResultsOf 182 patients, 60.4% had bone and 39.6% had soft-tissue eCHS. eCHS were of conventional (31.9%), myxoid (28.6%; 41 extraskeletal, 11 skeletal), mesenchymal (9.9%), or other subtypes. En-bloc surgery with complete resection was performed in 52.6% and poRT in 36.8% of patients (median dose, 54 Gy). Irradiated patients had unfavorable initial characteristics, with higher grade and incomplete resection. Median follow-up time was 61 months. Five-year incidence of local relapse was 10% with poRT versus 21.6% without (P = .050). Using the IPTW method, poRT reduced the local relapse risk (hazard ratio, 0.27; 95% confidence interval, 0.14-0.52; P < .001). Five-year disease-free survival (DFS) was 71.8% with poRT and 64.2% without (P = .680). Using the IPTW method, poRT improved DFS (hazard ratio, 0.51; 95% confidence interval, 0.30-0.85; P = .010). The benefit of poRT on local relapse and DFS was confirmed after exclusion of the extraskeletal subtype. There was no difference in overall survival. Prognostic factors of poorer DFS in multivariate analysis were deeper location, higher grade, incomplete resection, and no poRT.ConclusionspoRT should be offered in patients with eCHS and high-grade or incomplete resection, regardless of the histologic subtype. |
| Databáze: | OpenAIRE |
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