Dissecting the signaling pathways involved in the function of sperm flagellum
| Autor: | Lenka Vyklicka, Polina V. Lishko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
1.1 Normal biological development and functioning Motility Flagellum Biology Article 03 medical and health sciences 0302 clinical medicine CatSper Underpinning research Capacitation Compartment (development) Animals Humans Slo1 Progesterone Sperm ion channels Ion channel Sperm motility Slo3 030304 developmental biology 0303 health sciences Sperm flagellum pH Contraception/Reproduction Cell Biology Spermatozoa Cell biology EFCAB9 Fertility Ion homeostasis Infertility Sperm Tail Motile cilium Sperm Motility Calcium Biochemistry and Cell Biology Calcium Channels Hv1 030217 neurology & neurosurgery Developmental Biology Signal Transduction |
| Zdroj: | Curr Opin Cell Biol |
| Popis: | The mammalian flagellum is a specific type of motile cilium required for sperm motility and male fertility. Effective flagellar movement is dependent on axonemal function, which in turn relies on proper ion homeostasis within the flagellar compartment. This ion homeostasis is maintained by the concerted function of ion channels and transporters that initiate signal transduction pathways resulting in motility changes. Advances in electrophysiology and super-resolution microscopy have helped to identify and characterize new regulatory modalities of the mammalian flagellum. Here, we discuss what is currently known about the regulation of flagellar ion channels and transporters that maintain sodium, potassium, calcium, and proton homeostasis. Identification of new regulatory elements and their specific roles in sperm motility is imperative for improving diagnostics of male infertility. |
| Databáze: | OpenAIRE |
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