Cardiac Amyloidosis Shows Decreased Diastolic Function as Assessed by Echocardiographic Parameterized Diastolic Filling
| Autor: | Peter Cain, Katrin Salman, Martin Ugander, Benjamin T. Fitzgerald, Martin Sundqvist |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Acoustics and Ultrasonics Biophysics Diastole 030204 cardiovascular system & hematology Doppler echocardiography Sensitivity and Specificity Ventricular Dysfunction Left 03 medical and health sciences 0302 clinical medicine Left atrial Internal medicine Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Diastolic function 030212 general & internal medicine Interventricular septum Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Amyloidosis Reproducibility of Results Stroke Volume Stroke volume Middle Aged medicine.disease medicine.anatomical_structure Cardiac amyloidosis Echocardiography Cardiology Female business Blood Flow Velocity |
| Zdroj: | Ultrasound in Medicine & Biology. 43:1331-1338 |
| ISSN: | 0301-5629 |
| Popis: | Cardiac amyloidosis is a rare but serious condition with poor survival. One of the early findings by echocardiography is impaired diastolic function, even before the development of cardiac symptoms. Early diagnosis is important, permitting initiation of treatment aimed at improving survival. The parameterized diastolic filling (PDF) formalism entails describing the left ventricular filling pattern during early diastole using the mathematical equation for the motion of a damped harmonic oscillator. We hypothesized that echocardiographic PDF analysis could detect differences in diastolic function between patients with amyloidosis and controls. Pulsed-wave Doppler echocardiography of transmitral flow was measured in 13 patients with amyloid heart disease and 13 age- and gender matched controls. E- waves (2 to 3 per subject) were analyzed using in-house developed software. Nine PDF-derived parameters were obtained in addition to conventional echocardiographic parameters of diastolic function. Compared to controls, cardiac amyloidosis patients had a larger left atrial area (23.7 ± 7.5 cm2 vs. 18.5 ± 4.8 cm2, p = 0.04), greater interventricular septum wall thickness (14.4 ± 2.6 mm vs. 9.3 ± 1.3 mm, p |
| Databáze: | OpenAIRE |
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