The Role of Allogeneic Epidermis in Murine Graft Rejection
| Autor: | M B Lerner-Tung, B E Hull |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Graft Rejection
Male Pathology medicine.medical_specialty Peripheral blood mononuclear cell Mice Culture Techniques medicine Animals General Nursing Skin integumentary system Graft rejection Epidermis (botany) business.industry Rehabilitation Skin Transplantation Fibroblasts medicine.disease Rats Inbred F344 Rats General Health Professions Mice Inbred CBA Emergency Medicine Surgery Collagen Epidermis business Infiltration (medical) |
| Zdroj: | Journal of Burn Care & Rehabilitation. 10:151-155 |
| ISSN: | 0273-8481 |
| DOI: | 10.1097/00004630-198903000-00009 |
| Popis: | Skin equivalents containing allogeneic fibroblasts in a collagen matrix and overlaid with isologous epidermal cells have been successfully grafted to rodents. By contrast, skin equivalents containing isologous fibroblasts and allogeneic epidermal cells provoke a strong rejection response, characterized by the infiltration of mononuclear cells into the epidermis at 1 week and occlusion of the microvasculature and destruction of the epidermis by lymphocytes 2 weeks after grafting. Based on these findings, skin equivalents containing allogeneic fibroblasts could be used in the treatment of burn injuries, but the epidermis should be obtained from the patient. |
| Databáze: | OpenAIRE |
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