Effect of renal sympathetic nerve on adrenergically and angiotensin II-induced renal vasoconstriction in normal Wistar-Kyoto rats
| Autor: | Fathihah Basri, Munavvar A. Sattar, Mohammed H. Abdulla, Kolla R. L. Anand Swarup, Raisa N. Kazi, Nor Azizan Abdullah, Abdul H. Khan, Edward J. Johns, Hassaan A. Rathore |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System α1-Adrenoceptors losartan Wistar-Kyoto rats Adrenergic Blood Pressure carvedilol Kidney urologic and male genital diseases Rats Inbred WKY Receptor Angiotensin Type 1 Methoxamine Renal Circulation Norepinephrine Receptors Adrenergic alpha-1 Internal medicine medicine Animals Renal circulation business.industry Angiotensin II renal haemodynamics General Medicine Rats Endocrinology medicine.anatomical_structure Losartan Vasoconstriction Renal blood flow cardiovascular system Original Article Adrenergic alpha-1 Receptor Agonists medicine.symptom business medicine.drug |
| Zdroj: | Upsala Journal of Medical Sciences |
| ISSN: | 2000-1967 0300-9734 |
| DOI: | 10.3109/03009734.2010.526723 |
| Popis: | Background. This study examined the effect of renal sympathetic innervation on adrenergically and angiotensin II (Ang II)induced renal vasoconstriction in Wistar-Kyoto (WKY) rats. Methods. Forty-eight WKY rats were treated with either losartan (10 mg/kg/day p.o.) or carvedilol (5 mg/kg/day p.o.) or a combination of them (10 mg/kg/day + 5 mg/kg/day p.o.) for 7 days. On day 8, the rats were anaesthetized, and renal vasoconstrictor experiments were carried out. A group of rats was subjected to acute unilateral renal denervation during the acute study. Changes in the renal vasoconstrictor responses were determined in terms of reductions in renal blood flow caused by Ang II, noradrenaline (NA), and methoxamine (ME). Results. In normal animals, losartan decreased (P < 0.05) the renal vasoconstrictor response to Ang II but not to NA or ME. Carvedilol treatment, however, blunted (P < 0.05) the renal vasoconstrictor responses to Ang II and adrenergic agonists. Combination of losartan and carvedilol blunted (P < 0.05) the renal vasoconstrictor response to Ang II but augmented the responses to NA and ME (all P < 0.05). Interestingly, when denervated rats were treated with the same combination, there was a reduction (P < 0.05) in the renal vasoconstrictor responses to Ang II and adrenergic agonists. Conclusions. Data suggest that the renal sympathetic nerve contributes to adrenergic agonist-mediated renal vasoconstrictions in normal rats. The data further indicate an interactive relationship between renin-angiotensin and sympathetic nervous systems in modulating adrenergically and Ang II-induced renal vasoconstriction in WKY rats. |
| Databáze: | OpenAIRE |
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