Common variants in PCSK1 influence blood pressure and body mass index
| Autor: | X. Gao, Q Gu, M. van Hoek, Mojgan Yazdanpanah, A. Hofman, F W M de Rooij, Eric J.G. Sijbrands |
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| Přispěvatelé: | Internal Medicine, Epidemiology |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Genotype Population Blood Pressure Type 2 diabetes White People Body Mass Index Rotterdam Study SDG 3 - Good Health and Well-being Internal medicine Internal Medicine medicine Humans Insulin Genetic Predisposition to Disease Obesity education Proinsulin Aged education.field_of_study business.industry Odds ratio Middle Aged medicine.disease Blood pressure Endocrinology Diabetes Mellitus Type 2 Proprotein Convertase 1 Hypertension Female business Body mass index |
| Zdroj: | Journal of Human Hypertension, 29(2), 82-86. Nature Publishing Group |
| ISSN: | 1476-5527 0950-9240 |
| Popis: | Proprotein convertase subtilisin/kexin-type 1 (PCSK1) activates precursors pro-opiomelanocortin (POMC), proinsulin and prorenin. We investigated if common variants in the PCSK1 gene influence blood pressure and risk of hypertension. Additionally, we investigated the risk of obesity and type 2 diabetes (T2D). In the Rotterdam Study (RS1), a prospective, population-based cohort (n = 5974), four single-nucleotide polymorphisms (rs10515237, rs6232, rs436321 and rs3792747) in PCSK1 were studied. Linear and Cox regression models served to analyze associations between variants and end points. Replication was performed in the Rotterdam Study Plus1 (RSPlus1, n = 1895). Rs436321 was significantly associated with systolic and diastolic blood pressure and risk of hypertension (odds ratio (OR): 1.1-1.3; P |
| Databáze: | OpenAIRE |
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