Differential asthma odds following respiratory infection in children from three minority populations

Autor: Rajesh Kumar, Jennifer R. Elhawary, William Rodriguez-Cintron, Thomas J. Nuckton, Emerita Brigino-Buenaventura, Sam S. Oh, Luisa N. Borrell, Jose R. Rodriguez-Santana, Brian Plotkin, Sandra Salazar, Shannon Thyne, Kelley Meade, Esteban G. Burchard, Max A. Seibold, Celeste Eng, Michael A. LeNoir, Eric M. Wohlford, Denise Serebrisky, Harold J. Farber
Přispěvatelé: Othumpangat, Sreekumar
Jazyk: angličtina
Rok vydání: 2020
Předmět:
RNA viruses
Male
Mexican People
Pulmonology
Pathology and Laboratory Medicine
medicine.disease_cause
Logistic regression
Families
0302 clinical medicine
Mexican Americans
Medicine and Health Sciences
Ethnicities
030212 general & internal medicine
Young adult
African American people
Child
Lung
Children
Respiratory Tract Infections
Pediatric
African Americans
Multidisciplinary
Respiratory infection
Hispanic or Latino
Population groupings
Infectious Diseases
Medical Microbiology
Viral Pathogens
Child
Preschool
Viruses
Respiratory
Bronchitis
Medicine
Female
Pathogens
Rhinovirus
Hispanic Americans
geographic locations
Research Article
Adolescent
General Science & Technology
Science
education
Microbiology
03 medical and health sciences
Young Adult
Clinical Research
medicine
Humans
Preschool
Microbial Pathogens
Asthma
Biology and life sciences
business.industry
Organisms
Infant
Latin American people
Pneumonia
medicine.disease
United States
Black or African American
Logistic Models
030228 respiratory system
Age Groups
Bronchiolitis
Respiratory Infections
Paramyxoviruses
Respiratory Syncytial Virus
People and places
business
Demography
Zdroj: PLoS ONE, Vol 15, Iss 5, p e0231782 (2020)
PloS one, vol 15, iss 5
PLoS ONE
ISSN: 1932-6203
Popis: Author(s): Wohlford, Eric M; Borrell, Luisa N; Elhawary, Jennifer R; Plotkin, Brian; Oh, Sam S; Nuckton, Thomas J; Eng, Celeste; Salazar, Sandra; LeNoir, Michael A; Meade, Kelley; Farber, Harold J; Serebrisky, Denise; Brigino-Buenaventura, Emerita; Rodriguez-Cintron, William; Kumar, Rajesh; Thyne, Shannon; Seibold, Max A; Rodriguez-Santana, Jose R; Burchard, Esteban G | Abstract: RATIONALE:Severe early-life respiratory illnesses, particularly those caused by respiratory syncytial virus (RSV) and human rhinovirus (HRV), are strongly associated with the development of asthma in children. Puerto Rican children in particular have a strikingly high asthma burden. However, prior studies of the potential associations between early-life respiratory illnesses and asthma in Puerto Rican and other minority populations have been limited. OBJECTIVES:We sought to determine whether early-life respiratory illness was associated with asthma in Puerto Rican, Mexican American, and African American children. METHODS:Using a logistic regression analysis, we examined the association between early-life respiratory illnesses (report of upper respiratory infection (URI), pneumonia, bronchitis, and bronchiolitis/RSV) within the first two years of life and physician-diagnosed asthma after the age of two in a large cohort of Puerto Rican, Mexican American, and African American children. MEASUREMENTS AND MAIN RESULTS:While early-life respiratory illnesses were associated with greater asthma odds in Puerto Ricans, Mexican Americans, and African Americans, these associations were stronger among Puerto Rican children. Specifically, in Puerto Ricans, the odds was 6.15 (95% CI: 4.21-9.05) if the child reported at least one of the following respiratory illness: URI, pneumonia, bronchitis or bronchiolitis. The odds were also higher in Puerto Ricans when considering these conditions separately. CONCLUSIONS:We observed population-specific associations between early-life respiratory illnesses and asthma, which were especially significant and stronger in Puerto Ricans. Taken together with the known high burden of RSV in Puerto Rico, our results may help explain the high burden of asthma in Puerto Ricans.
Databáze: OpenAIRE
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