Does endogenous serum oestrogen play a role in meibomian gland dysfunction in postmenopausal women with dry eye?
| Autor: | Noor Ezailina Badarudin, Blanka Golebiowski, John John Eden, Ulrike Hampel, Fiona Stapleton, Jingjing You |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Physiology Meibomian gland Dry Eye Syndromes Enzyme-Linked Immunosorbent Assay 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Dehydroepiandrosterone sulfate Internal medicine Medicine Humans Ocular Surface Disease Index Tear secretion Aged Aged 80 and over business.industry Meibomian Glands Estrogens Middle Aged medicine.disease eye diseases Sensory Systems Menopause Postmenopause Ophthalmology 030104 developmental biology medicine.anatomical_structure Endocrinology Cross-Sectional Studies chemistry Tears 030221 ophthalmology & optometry Regression Analysis Female sense organs business Conjunctiva Hormone |
| Zdroj: | The British journal of ophthalmology. 101(2) |
| ISSN: | 1468-2079 |
| Popis: | Aim To explore the relationship between serum concentration of sex hormones and dry eye symptoms and signs in postmenopausal women. Methods A cross-sectional analysis was undertaken. Subjects were 46 postmenopausal women with dry eye (mean age 64.4±5.2 years, 13.7±6.4 years since menopause; not undergoing hormone replacement therapy). Ocular symptoms (Ocular Surface Disease Index (OSDI) and Ocular Comfort Index (OCI)), tear function (tear osmolarity, non-invasive tear break-up time, tear secretion), corneal and conjunctival staining, and meibomian gland (MG) appearance, were recorded. Venous blood was collected and serum concentrations of 17β-oestradiol (E2), 3-α-androstanediol-glucuronide (3α-diol-G), and dehydroepiandrosterone sulfate (DHEA-S) were determined using ELISA. Multiple linear regression analysis was used to examine predictors of dry eye symptoms and signs. Results Mean serum concentration of E2, 3α-diol-G and DHEA-S was 9.02±13.40 pg/mL, 1.59±1.02 ng/mL and 0.74±0.53 μg/mL, respectively. Ocular symptoms were elevated (mean scores 27.0±18.1 (OSDI) and 40.3±8.4 (OCI)) but signs were within normal ranges. Higher serum E2 concentration along with capped glands, lid telangiectasia and older age was a significant predictor of worse MG secretion quality (p 2 adj=0.75). Serum hormones were not significant predictors of ocular symptoms in multivariate analysis (p>0.05). Conclusion Serum oestrogen appears to be a key factor in MG signs. Although serum hormone levels did not contribute significantly to dry eye symptoms in this study, it is possible that oestrogen plays a role through its effect on meibum secretion. These findings suggest that MG dysfunction underpins dry eye symptoms in non-Sjogren9s dry eye in postmenopausal women. Trial registration number ACTRN12612000281897. |
| Databáze: | OpenAIRE |
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