Influence of Highly Distinctive Structural Properties on the Excitability of Pyramidal Neurons in Monkey Visual and Prefrontal Cortices
| Autor: | Patrick R. Hof, Jennifer I. Luebke, Joseph M. Amatrudo, Johanna L. Crimins, Douglas L. Rosene, Christina M. Weaver |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Patch-Clamp Techniques Dendritic spine Dendritic Spines Models Neurological Action Potentials Prefrontal Cortex In Vitro Techniques Neurotransmission Biology Synaptic Transmission Article Tonic (physiology) medicine Animals Prefrontal cortex Visual Cortex Neurons Membrane potential Microscopy Confocal Pyramidal Cells General Neuroscience Excitatory Postsynaptic Potentials Macaca mulatta Visual cortex medicine.anatomical_structure Inhibitory Postsynaptic Potentials nervous system Organ Specificity Excitatory postsynaptic potential Female Non-spiking neuron Neuroscience |
| Zdroj: | The Journal of Neuroscience. 32:13644-13660 |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | Whole-cell patch-clamp recordings and high-resolution 3D morphometric analyses of layer 3 pyramidal neurons inin vitroslices of monkey primary visual cortex (V1) and dorsolateral granular prefrontal cortex (dlPFC) revealed that neurons in these two brain areas possess highly distinctive structural and functional properties. Area V1 pyramidal neurons are much smaller than dlPFC neurons, with significantly less extensive dendritic arbors and far fewer dendritic spines. Relative to dlPFC neurons, V1 neurons have a significantly higher input resistance, depolarized resting membrane potential, and higher action potential (AP) firing rates. Most V1 neurons exhibit both phasic and regular-spiking tonic AP firing patterns, while dlPFC neurons exhibit only tonic firing. Spontaneous postsynaptic currents are lower in amplitude and have faster kinetics in V1 than in dlPFC neurons, but are no different in frequency. Three-dimensional reconstructions of V1 and dlPFC neurons were incorporated into computational models containing Hodgkin–Huxley and AMPA receptor and GABAAreceptor gated channels. Morphology alone largely accounted for observed passive physiological properties, but led to AP firing rates that differed more than observed empirically, and to synaptic responses that opposed empirical results. Accordingly, modeling predicts that active channel conductances differ between V1 and dlPFC neurons. The unique features of V1 and dlPFC neurons are likely fundamental determinants of area-specific network behavior. The compact electrotonic arbor and increased excitability of V1 neurons support the rapid signal integration required for early processing of visual information. The greater connectivity and dendritic complexity of dlPFC neurons likely support higher level cognitive functions including working memory and planning. |
| Databáze: | OpenAIRE |
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