Choroid plexus tumors in children less than 36 months: the Canadian Pediatric Brain Tumor Consortium (CPBTC) experience
| Autor: | Beverly Wilson, Lucie Lafay-Cousin, Chris Fryer, Daniel L. Keene, Shayna Zelcer, David D. Eisenstat, Valerie Larouche, Bruce Crooks, Josee Brossard, M. Silva, Ute Bartels, Donna L. Johnston, Eric Bouffet, Anne-Sophie Carret |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Oncology Canada Choroid Plexus Neoplasms medicine.medical_specialty Pediatric Brain Tumor Consortium Population Antineoplastic Agents Kaplan-Meier Estimate macromolecular substances Disease-Free Survival Neurosurgical Procedures Internal medicine medicine Carcinoma Humans Age of Onset Choroid plexus tumor education education.field_of_study business.industry Incidence Infant Newborn technology industry and agriculture Infant General Medicine Choroid plexus carcinoma Prognosis medicine.disease Choroid plexus papilloma Surgery Chemotherapy Adjuvant Child Preschool Pediatrics Perinatology and Child Health Female Papilloma Choroid Plexus Choroid plexus Neurology (clinical) Choroid Plexus Neoplasm business |
| Zdroj: | Child's Nervous System. 27:259-264 |
| ISSN: | 1433-0350 0256-7040 |
| DOI: | 10.1007/s00381-010-1269-9 |
| Popis: | Choroid plexus tumors (CPT) are rare pediatric tumors. A population-based study on choroid plexus carcinoma (CPC) and choroid plexus papilloma (CPP) was carried out to describe the incidence, demographic, and outcome data and to identify potential prognostic factors.The CPT population from the Canadian databank of CNS tumor in children ≤ 36 months diagnosed between 1990 and 2005 was reviewedOut of the 579 reported cases of CNS tumors, 37 were CPT. The annual age-adjusted incidence rate was 0.22 + 0.12 (95% CI 0.16-0.28)/100,000 children3 years. There were 21 (56.7%) CPP and 16 (43.3.5%) CPC. Twenty patients (54%) were males. Median age at diagnosis was 7 months(range 0-30). Ten patients(62.5%) with CPC and one with CPP were metastatic at diagnosis. Twenty patients with CPP (95%) had a complete resection, whereas 6/16 CPC (37.5%) achieved a resection90%. Fourteen CPC patients received adjuvant chemotherapy. None of the 37 patients received adjuvant radiation. At completion of survey, all CPP and five CPC were alive. Median survival time for CPC patients was 15 months (0-120). One death was related to intraoperative hemorrhage, another to chemotherapy-induced toxicity, and one to secondary AML. Age at diagnosis, degree of resection and metastatic status were not significant prognostic factors for CPC.By contrast to CPC, CPP have an excellent prognosis following surgery alone. Survival of CPC remains poor. However, these data may suggest adjuvant chemotherapy can alter the aggressive natural history of CPC. As with other rare CNS tumors, international collaboration is required to identify optimal therapy. |
| Databáze: | OpenAIRE |
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