Immunological impact of an additional early measles vaccine in Gambian children: Responses to a boost at 3 years
| Autor: | Assan Jaye, Marianne A B van der Sande, David Miles, Samuel Nyamweya, Katie L. Flanagan, Jane U. Adetifa, David Jeffries, Sarah Rowland-Jones, Safayet Hossin, Syed M. A. Zaman, Melba S. Palmero, Hilton Whittle, Jainaba Njie-Jobe, Ebrima S. Touray, Sarah Burl |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Cellular immunity
T-Lymphocytes Measles Vaccine Immunization Secondary Two-dose schedule Booster dose Antibodies Viral Measles Article Measles virus Interferon-gamma Immune system Immunology and Microbiology(all) medicine Humans Antibody General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health Infant Forkhead Transcription Factors biology.organism_classification medicine.disease veterinary(all) Infectious Diseases Immunization Child Preschool Immunology biology.protein Molecular Medicine Cytokines Gambia Measles vaccine business Immunologic Memory |
| Zdroj: | Vaccine |
| ISSN: | 0264-410X |
| Popis: | Highlights ► Gambian infants were given one or two doses of measles vaccine. ► The kinetics of the immune response was compared after a boost. ► Antibody responses were equally rapid and high. ► Cell mediated responses were insignificantly different. ► Antibody concentrations decayed quicker in the two dose group. Background Measles vaccine in early infancy followed by a dose at 9 months of age protects against measles and enhances child survival through non-specific effects. Little is known of immune responses in the short or long term after booster doses. Methods Infants were randomized to receive measles vaccine at 9 months of age (group 1) or 4 and 9 months of age (group 2). Both groups received a boost at 36 months of age. T-cell effector and memory responses using IFN-γ ELIspot and cytokine assays and antibody titres using a haemagglutination-inhibition assay were compared at various times. Results Vaccination at 4 months of age elicited antibody and CD4 T-cell mediated immune responses .Two weeks after vaccination at 9 months of age group 2 had much higher antibody titres than group1 infants; cell-mediated effector responses were similar. At 36 months of age group 2 antibody titres exceeded protective levels but were 4-fold lower than group 1; effector and cytokine responses were similar. Re-vaccination resulted in similar rapid and high antibody titres in both groups (median 512); cellular immunity changed little. At 48 months of age group 2 antibody concentrations remained well above protective levels though 2-fold lower than group 1; T-cell memory was readily detectable and similar in both groups. Conclusions An additional early measles vaccine given to children at 4 months of age induced a predominant CD4 T-cell response at 9 months and rapid development of high antibody concentrations after booster doses. However, antibody decayed faster in these children than in the group given primary vaccination at 9 months of age. Cellular responses after 9 months were generally insignificantly different. |
| Databáze: | OpenAIRE |
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