The effect of 3-methyl substitution on the carcinogenicity of nitroso-4-piperidone
| Autor: | George M. Singer, William Lijinsky, Mario M. Mangino, Melvin D. Reuber |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Cancer Research
Nitrosamines Esophageal Neoplasms Molecular Conformation Pharmacology Potable water chemistry.chemical_compound Structure-Activity Relationship Liver Neoplasms Experimental Esophageal tumors medicine Animals Esophagus Carcinogen General Medicine Nitroso Neoplasms Experimental Rats Inbred F344 Rats medicine.anatomical_structure Biochemistry chemistry Nitrosamine Carcinogens Female Derivative (chemistry) Methyl group |
| Zdroj: | Carcinogenesis. 5(10) |
| ISSN: | 0143-3334 |
| Popis: | The carcinogenic activity of the 3-methyl derivative of nitroso-4-piperidone was compared with that of the compound without the methyl group, by chronic administration to rats at equimolar doses in drinking water. Nitrosopiperidone induced both liver and esophageal tumors, whereas the 3-methyl derivative induced only tumors of the esophagus in a much shorter time. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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