Ethnic influence on nonalcoholic fatty liver disease prevalence and lack of disease awareness in the United States, 2011–2016

Autor: Vincent Wai-Sun Wong, Michael H. Le, Ramsey Cheung, Mindie H. Nguyen, Yee Hui Yeo
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
Health Knowledge
Attitudes
Practice
medicine.medical_specialty
Hepatitis
Viral
Human
National Health and Nutrition Examination Survey
Ethnic group
Disease
030204 cardiovascular system & hematology
digestive system
White People
Young Adult
03 medical and health sciences
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Surveys and Questionnaires
Environmental health
Mexican Americans
Nonalcoholic fatty liver disease
Ethnicity
Prevalence
Internal Medicine
Humans
Medicine
Asian
business.industry
Public health
Racial Groups
Fatty liver
nutritional and metabolic diseases
Hispanic or Latino
Middle Aged
Nutrition Surveys
medicine.disease
United States
digestive system diseases
Black or African American
Alcoholism
030104 developmental biology
Population study
Female
business
Viral hepatitis
Zdroj: Journal of Internal Medicine. 287:711-722
ISSN: 1365-2796
0954-6820
DOI: 10.1111/joim.13035
Popis: Background Nonalcoholic fatty liver disease (NAFLD) is a rising global disease associated with clinical and economic burdens. Objectives We aimed to quantify NAFLD prevalence and awareness to provide stakeholders necessary information to combat NAFLD burden. Methods This study utilizes data from the National Health and Nutrition Examination Survey 2011-2016 and included 4538 adult participants who did not have heavy drinking or viral hepatitis history. The US fatty liver index defined NAFLD and NAFLD fibrosis score defined fibrosis. NAFLD awareness was captured by questionnaire. Results Amongst the study population of 4538 persons, NAFLD prevalence was 32.5%, lowest in non-Hispanic Blacks (18.0%) and Asians (18.1%), highest amongst Mexican Americans (48.4%). Within the NAFLD group, advanced fibrosis was highest in non-Hispanic Blacks (28.5%) and lowest amongst non-Hispanic Asians (2.7%). Of the 1473 (97.5%) NAFLD participants who answered NAFLD awareness question, 90% visited a healthcare centre at least once in the past year, but only 5.1% were aware of having NAFLD. On weighted population estimates, 77.33 million persons had NAFLD, 17.63 million had advanced fibrosis, and 73.39 million NAFLD participants were not aware of having NAFLD. Conclusions Of 77.33 million people in the United States have NAFLD with 17.63 million having advanced fibrosis, with lowest prevalence in non-Hispanic Asians and highest in Mexican Americans. A conundrum exists amongst non-Hispanic Blacks who have low NAFLD prevalence but highest prevalence of advanced fibrosis. Awareness of NAFLD was low across all ethnicities. Effort is needed to improve disease awareness whilst addressing NAFLD clinical burden across ethnicities.
Databáze: OpenAIRE
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