SPECIFIC CELL-MEDIATED IMMUNE DEFECT IN ACTIVE CYTOMEGALOVIRUS INFECTION OF YOUNG CHILDREN AND THEIR MOTHERS
| Autor: | Henry H. Balfour, S. O. Knorr, R. C. Gehrz, Janal M. Kalis, Stephen C. Marker |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
Male Offspring Congenital cytomegalovirus infection Cytomegalovirus In Vitro Techniques Biology Antibodies Viral Virus Replication Virus Immune system Antigen Pregnancy Immunity medicine Humans Lymphocytes Maternal-Fetal Exchange Immunity Cellular Immunologic Deficiency Syndromes Infant Newborn Infant General Medicine Acquired immune system medicine.disease Virology Child Preschool Carrier State Cytomegalovirus Infections Immunology Immunologic Techniques biology.protein Female Antibody |
| Zdroj: | The Lancet. 310:844-847 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(77)90782-6 |
| Popis: | 4 young children with active cytomegalovirus (C.M.V.) infection were found, by an in-vitro lymphocyte-proliferation assay, to have a C.M.V.-specific cell-mediated immune defect. These children had antibodies to C.M.V. and were actively shedding C.M.V. in the urine when studied. Their general cellular immune responses were intact, with normal numbers of T lymphocytes and normal in-vitro responses to mitogens and at least one antigen. 3 of the 4 mothers studied shortly after delivery had decreased cell-mediated immunity to C.M.V. These findings suggest that an antigen-specific immune defect facilitates transmission of virus from mother to infant and permits persistence of viral replication in the offspring. |
| Databáze: | OpenAIRE |
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