Aldosterone increases the amiloride-sensitivity of the rat gustatory neural response to NaCl
| Autor: | M. Scott Herness |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Taste medicine.medical_specialty medicine.drug_class Sodium chemistry.chemical_element Sodium Chloride Stimulus (physiology) Amiloride Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Animals Neurons Afferent Aldosterone Sodium channel Adrenalectomy Drug Synergism General Medicine Apical membrane Rats Electrophysiology Endocrinology chemistry Mineralocorticoid medicine.drug |
| Zdroj: | Comparative Biochemistry and Physiology Part A: Physiology. 103:269-273 |
| ISSN: | 0300-9629 |
| DOI: | 10.1016/0300-9629(92)90578-e |
| Popis: | 1. 1. The percentage inhibition of the chorda tympani neural response to NaCI by topical application of amiloride to the tongue was significantly larger in rats pretreated with aldosterone than in control animals. 2. 2. Adrenalectomized rats pretreated with aldosterone had significantly larger amiloride-induced inhibitions to a NaCl stimulus than did adrenalectomized control animals. 3. 3. These data suggest that aldosterone may increase the number of active amiloride-sensitive sodium channels in the apical membrane of taste cells, as is known to occur in sodium transporting tissues of amphibians and mammals. They additionally represent a previously unnoticed hormonal influence over the gustatory system. |
| Databáze: | OpenAIRE |
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