Author response: Acute elevation of serum inflammatory markers predicts symptom recovery after concussion
| Autor: | Timothy B. Meier, Morgan E. Nitta |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Agonist
medicine.medical_specialty Injury control business.industry Accident prevention medicine.drug_class Post-Concussion Syndrome Symptom severity Poison control medicine.disease 03 medical and health sciences 0302 clinical medicine Internal medicine Concussion Injury prevention Medicine Humans 030212 general & internal medicine Neurology (clinical) business 030217 neurology & neurosurgery Biomarkers Brain Concussion Posttraumatic amnesia |
| Zdroj: | Neurology. 94(24) |
| ISSN: | 1526-632X |
| Popis: | We thank Dr. Sethi for the comment and inquiry. In this sample,1 no concussed athletes reported loss of consciousness and only 2 athletes reported posttraumatic amnesia. Thus, we were unable to appropriately address the potential effects of these injury characteristics on the studied markers. Regarding the normalization of the inflammatory markers relative to symptom resolution, as seen in figure 2,1 the levels of interleukin-1 receptor agonist and interleukin-6 returned to the baseline levels by the 24–48-hour visit, whereas symptom severity scores remained elevated. That is, elevations in these inflammatory markers resolved before the symptoms did and the inflammatory markers only showed a prognostic promise when collected within 6 hours postinjury. |
| Databáze: | OpenAIRE |
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