Spatial Reference Memory is Associated with Modulation of Theta–Gamma Coupling in the Dentate Gyrus
| Autor: | Romain Goutagny, Julien Aubert, Chantal Mathis, Jean-Christophe Cassel, Marc-Antoine Muller, Jean-Bastien Bott, Jesse Jackson |
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| Přispěvatelé: | Laboratoire de neurosciences cognitives et adaptatives (LNCA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Department of Physiology, University of Alberta, Edmonton, Alberta, Canada |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Memory Long-Term Cognitive Neuroscience Hippocampus Local field potential Hippocampal formation Spatial memory Mice 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Gyrus Encoding (memory) medicine Animals Gamma Rhythm Cortical Synchronization Theta Rhythm ComputingMilieux_MISCELLANEOUS Spatial Memory Neuronal Plasticity Dentate gyrus Barnes maze 030104 developmental biology medicine.anatomical_structure Dentate Gyrus [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Nerve Net Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cerebral Cortex Cerebral Cortex, Oxford University Press (OUP), 2016, 26 (9), pp.3744-3753. ⟨10.1093/cercor/bhv177⟩ |
| ISSN: | 1047-3211 1460-2199 |
| DOI: | 10.1093/cercor/bhv177⟩ |
| Popis: | Spatial reference memory in rodents represents a unique opportunity to study brain mechanisms responsible for encoding, storage and retrieval of a memory. Even though its reliance on hippocampal networks has long been established, the precise computations performed by different hippocampal subfields during spatial learning are still not clear. To study the evolution of electrophysiological activity in the CA1-dentate gyrus axis of the dorsal hippocampus over an iterative spatial learning paradigm, we recorded local field potentials in behaving mice using a newly designed appetitive version of the Barnes maze. We first showed that theta and gamma oscillations as well as theta-gamma coupling are differentially modulated in particular hippocampal subfields during the task. In addition, we show that dentate gyrus networks, but not CA1 networks, exhibit a transient learning-dependent increase in theta-gamma coupling specifically at the vicinity of the target area in the maze. In contrast to previous immediate early-gene studies, our results point to a long-lasting involvement of dentate networks in navigational memory in the Barnes maze. Based on these findings, we propose that theta-gamma coupling might represent a mechanism by which hippocampal areas compute relevant information. |
| Databáze: | OpenAIRE |
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