Rapid detection for infected ascites in cirrhosis using metagenome next‐generation sequencing: A case series
| Autor: | Yan Chen, Rajiv Jalan, Yongyu Rui, Jinjun Chen, Beiling Li, Qinjun He |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Cirrhosis Hepatology business.industry Ascites High-Throughput Nucleotide Sequencing Bacterial Infections Peritonitis medicine.disease Gastroenterology DNA sequencing Spontaneous bacterial peritonitis Infected ascites Infectious disease (medical specialty) Metagenomics Internal medicine medicine Humans Metagenome medicine.symptom business Pathogen |
| Zdroj: | Liver International. 42:173-179 |
| ISSN: | 1478-3231 1478-3223 |
| DOI: | 10.1111/liv.15083 |
| Popis: | Empirical antibiotic therapy in patients with spontaneous bacterial peritonitis (SBP) is common as pathogen(s) are identified in only 5%-20% patients using conventional culture-based techniques. Metagenome next-generation sequencing (mNGS) test is a promising approach for the diagnosis of infectious disease. The clinical application of mNGS for infected ascites in cirrhotic patients is rarely reported. Here, we describe three cases to preliminarily explore the potential role of mNGS for microbiological diagnosis of ascites infection in an exploratory manner. The clinical performance of ascites mNGS in cirrhotic patients remains to be further evaluated. |
| Databáze: | OpenAIRE |
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