Facile Synthetic Protocols for the Preparation of New Impurities in Pemetrexed Disodium Heptahydrate as an Anti-cancer Drug

Autor:	Rama Mohana Reddy Jaggavarapu, Venkatanarayana Muvvala, Venkatareddy Ghojala, H. Sharath Babu, Ravi Kumar Cheedarala
Rok vydání:	2022
Předmět:	Guanine Chemistry Pemetrexed disodium Organic Chemistry Antineoplastic Agents Pemetrexed Biochemistry Combinatorial chemistry Glutamates Impurity Anti cancer drugs medicine Spectral analysis medicine.drug Pemetrexed disodium heptahydrate
Zdroj:	Current Organic Synthesis. 19:2-9
ISSN:	1570-1794
Popis:	Abstract: A facile synthetic protocol was employed to prepare process-related impurities associated with the synthesis of pemetrexed disodium heptahydrate, Alimta. The research work is described for the development of the novel synthetic methods and their structure elucidation of Pemetrexed glutamide, N-methyl pemetrexed, and N-methyl pemetrexed glutamide impurities. The listed impurities were deduced through spectral analysis, such as 1H-NMR, 13CNMR, and HRMS. The target compounds can be used as the reference substances for quality control.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1824e461d6e02ed6196517e4c44286d https://doi.org/10.2174/1570179418666210114145914 Zobrazit plný text záznamu