Gouania willdenowi is a teleost fish without immunoglobulin genes
| Autor: | David N. Olivieri, Francisco Gambón-Deza, Serafin Mirete-Bachiller |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
T-Lymphocytes Immunology B-cell receptor Immunoglobulins Receptors Antigen B-Cell Locus (genetics) Biology Immunoglobulin light chain Genome 03 medical and health sciences 0302 clinical medicine medicine Animals Receptor Molecular Biology Gene B cell B-Lymphocytes Genes Immunoglobulin Fishes breakpoint cluster region Receptors Antigen T-Cell gamma-delta biology.organism_classification Molecular biology 030104 developmental biology medicine.anatomical_structure Gouania willdenowi Chromosomal region biology.protein Immunoglobulin Constant Region Antibody Transcriptome CD79 Antigens 030215 immunology |
| Zdroj: | Molecular Immunology. 132:102-107 |
| ISSN: | 0161-5890 |
| DOI: | 10.1016/j.molimm.2021.01.022 |
| Popis: | In the study of immunoglobulin V genes in fish genomes, we found that the species Gouania willdenowi does not possess any such regions, neither for the heavy chain nor for the light chains. Also, genes that code for the immunoglobulin constant regions were also not found. A detailed analysis of the chromosomal region of these genes revealed a deletion in the entire locus for regions of the heavy and light chains. These studies provide evidence that this species does not possess genes coding for immunoglobulins. Additionally, we found the genes that code for CD79a and CD79b protein molecules have also been deleted. Regions for the Tα/β lymphocyte receptors are present but the T γ/δ receptors were not found. In transcripts of two other Gobiesocidae species, Acystus sp. and Tomicodon sp., no antibody sequences could be detected, possibly indicating the absence of immunoglobulins in all species of this family. |
| Databáze: | OpenAIRE |
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