Association of vitamin D receptorBsmIgene polymorphism with the risk of type 2 diabetes mellitus
| Autor: | Bo Zhu, Hui-Liu Zhao, Ling-Sha Huang, Pei-Zhang Li, Ming Lao, Chao Ou |
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| Rok vydání: | 2014 |
| Předmět: |
Genetic Markers
China medicine.medical_specialty endocrine system diseases Cochrane Library Polymorphism Single Nucleotide Sensitivity and Specificity Biochemistry Calcitriol receptor Risk Factors Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Allele Molecular Biology Genetic Association Studies Genetic association business.industry Incidence Reproducibility of Results nutritional and metabolic diseases Type 2 Diabetes Mellitus Cell Biology Endocrinology Diabetes Mellitus Type 2 Meta-analysis Receptors Calcitriol Gene polymorphism business |
| Zdroj: | Journal of Receptors and Signal Transduction. 34:458-462 |
| ISSN: | 1532-4281 1079-9893 |
| DOI: | 10.3109/10799893.2014.919592 |
| Popis: | Relationship between vitamin D receptor (VDR) BsmI (rs1544410) gene polymorphism and the type 2 diabetes mellitus (T2DM) susceptibility is still conflicting at present. This meta-analysis was conducted to assess the association between VDR BsmI gene polymorphism and the risk of T2DM. The association studies were identified from PubMed, and Cochrane Library on 1 January 2014, and eligible investigations were included and synthesized using meta-analysis method. Eleven reports were recruited into this meta-analysis for the association of VDR BsmI gene polymorphism with T2DM susceptibility. In overall populations, B allele, BB genotype and bb genotype were not associated with T2DM risk. VDR BsmI gene polymorphism was also not associated with the T2DM risk in Asians and Caucasians. In conclusion, VDR BsmI gene polymorphism was also not associated with T2DM risk in overall populations, Asians and Caucasians. However, more studies should be conducted to confirm it. |
| Databáze: | OpenAIRE |
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