Relation of Serum Antioxidant Vitamins to the Risk of Colorectal Adenoma
| Autor: | N. Breuer, Harald Goebell, B. Leiendecker, A. Marr, B. Rump, K. Nemes, B. Breuer-Katschinski |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adenoma
Adult Male Vitamin medicine.medical_specialty endocrine system diseases medicine.medical_treatment Population Rectum Ascorbic Acid Colorectal adenoma Gastroenterology chemistry.chemical_compound Risk Factors Internal medicine medicine Humans Vitamin E Risk factor Vitamin A education Aged education.field_of_study business.industry Carotene Case-control study Middle Aged medicine.disease digestive system diseases stomatognathic diseases medicine.anatomical_structure Endocrinology chemistry Case-Control Studies Female Colorectal Neoplasms business |
| Zdroj: | Digestion. 63:43-48 |
| ISSN: | 1421-9867 0012-2823 |
| Popis: | The relation between risk of colorectal adenoma and serum concentrations of vitamins A, C, E and carotene was examined in a population-based case-control study of 105 cases of colorectal adenoma and a similar number of hospital controls showing no polyps at colonoscopy and a second control group of population controls. There were no significant associations with serum concentrations of vitamins C and E and carotene. Serum concentrations of vitamin A were significantly inversely related to the risk of colorectal adenoma when cases were compared with both control groups. After adjustment for energy intake, smoking, alcohol, estrogen therapy, body-mass-index and social class the inverse association between vitamin A and colorectal adenoma was even more marked. For the highest versus the lowest quartile of serum levels the adjusted RR was 0.23 (0.07–0.73) in relation to hospital controls and 0.08 (0.02–0.25) in relation to population controls. These findings suggest that the risk of developing colorectal adenomas is reduced in those with high vitamin A levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|