Circadian Clock Component BMAL1 in the Paraventricular Nucleus Regulates Glucose Metabolism
| Autor: | Masanori Nakata, Parmila Kumari, Rika Kita, Nanako Katsui, Yuriko Takeuchi, Tomoki Kawaguchi, Toshiya Yamazaki, Boyang Zhang, Shigeki Shimba, Toshihiko Yada |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
vasopressin glucose metabolism Article Mice Circadian Clocks Glucose Intolerance Animals Insulin insulin release TX341-641 RNA Messenger Mice Knockout Neurons Nutrition and Dietetics Nutrition. Foods and food supply urogenital system paraventricular nucleus circadian BMAL1 digestive oral and skin physiology ARNTL Transcription Factors Arginine Vasopressin Glucose Gene Expression Regulation nervous system hormones hormone substitutes and hormone antagonists Food Science Paraventricular Hypothalamic Nucleus |
| Zdroj: | Nutrients; Volume 13; Issue 12; Pages: 4487 Nutrients, Vol 13, Iss 4487, p 4487 (2021) Nutrients |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13124487 |
| Popis: | It is suggested that clock genes link the circadian rhythm to glucose and lipid metabolism. In this study, we explored the role of the clock gene Bmal1 in the hypothalamic paraventricular nucleus (PVN) in glucose metabolism. The Sim1-Cre-mediated deletion of Bmal1 markedly reduced insulin secretion, resulting in impaired glucose tolerance. The pancreatic islets’ responses to glucose, sulfonylureas (SUs) and arginine vasopressin (AVP) were well maintained. To specify the PVN neuron subpopulation targeted by Bmal1, the expression of neuropeptides was examined. In these knockout (KO) mice, the mRNA expression of Avp in the PVN was selectively decreased, and the plasma AVP concentration was also decreased. However, fasting suppressed Avp expression in both KO and Cre mice. These results demonstrate that PVN BMAL1 maintains Avp expression in the PVN and release to the circulation, possibly providing islet β-cells with more AVP. This action helps enhance insulin release and, consequently, glucose tolerance. In contrast, the circadian variation of Avp expression is regulated by feeding, but not by PVN BMAL1. |
| Databáze: | OpenAIRE |
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