MRI-based quantification of posterior ocular globe flattening during 60 days of strict 6° head-down tilt bed rest with and without daily centrifugation

Autor: Stuart H. Sater, Gabryel Conley Natividad, Akari J. Seiner, Audrey Q. Fu, Dev Shrestha, Eric M. Bershad, Karina Marshall-Goebel, Steven S. Laurie, Brandon R. Macias, Bryn A. Martin
Rok vydání: 2022
Předmět:
Zdroj: Journal of applied physiology (Bethesda, Md. : 1985). 133(6)
ISSN: 1522-1601
Popis: Spaceflight associated neuro-ocular syndrome (SANS) is associated with acquired optic disc edema, hyperopia, and posterior globe flattening in some astronauts during long-duration spaceflight possibly due to the headward fluid redistribution in microgravity. The goal of this study was to assess whether strict head-down tilt (HDT) bed rest as a spaceflight analog would produce globe flattening and whether centrifugation could prevent these changes. Twenty-four healthy subjects separated into three groups underwent 60 days of strict 6° HDT bed rest: one control group with no countermeasure (
Databáze: OpenAIRE