IL-7 and IL-15 Levels Reflect the Degree of T Cell Depletion during Lymphopenia and Are Associated with an Expansion of Effector Memory T Cells after Pediatric Hematopoietic Stem Cell Transplantation
| Autor: | Astrid G. S. van Halteren, Arjan C. Lankester, Marianne Ifversen, Lisa V E Oostenbrink, Robbert G. M. Bredius, Cornelia M. Jol-van der Zijde, Erik G J von Asmuth, Marco W. Schilham, Maarten J. D. van Tol, Anja M. Jansen-Hoogendijk, Klaus Müller, Katrine Kielsen, Carsten Heilmann, Monique M. van Ostaijen-ten Dam |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Adolescent medicine.medical_treatment T cell Immunology Hematopoietic stem cell transplantation Lymphocyte Depletion Memory T Cells Young Adult 03 medical and health sciences 0302 clinical medicine Lymphopenia Humans Immunology and Allergy Medicine Child Retrospective Studies Interleukin-15 Acute leukemia business.industry Interleukin-7 Hematopoietic Stem Cell Transplantation Infant Middle Aged Leukemia Myeloid Acute medicine.anatomical_structure Cytokine Interleukin 15 Child Preschool T cell differentiation Bone marrow business Memory T cell 030215 immunology |
| Zdroj: | Journal of Immunology, 206(12), 2828-2838. AMER ASSOC IMMUNOLOGISTS |
| Popis: | Differentially and functionally distinct T cell subsets are involved in the development of complications after allogeneic hematopoietic stem cell transplantation (HSCT), but little is known about factors regulating their recovery after HSCT. In this study, we investigated associations between immune-regulating cytokines, T cell differentiation, and clinical outcomes. We included 80 children undergoing allogeneic HSCT for acute leukemia using bone marrow or peripheral blood stem cells grafted from a matched sibling or unrelated donor. Cytokines (IL-7, IL-15, IL-18, SCF, IL-6, IL-2, and TNF-α) and active anti-thymocyte globulin (ATG) levels were longitudinally measured along with extended T cell phenotyping. The cytokine profiles showed a temporary rise in IL-7 and IL-15 during lymphopenia, which was strongly dependent on exposure to active ATG. High levels of IL-7 and IL-15 from graft infusion to day +30 were predictive of slower T cell recovery during the first 2 mo post-HSCT; however, because of a major expansion of memory T cell stages, only naive T cells remained decreased after 3 mo (p < 0.05). No differential effect was seen on polarization of CD4+ T cells into Th1, Th2, or Th17 cells or regulatory T cells. Low levels of IL-7 and IL-15 at day +14 were associated with acute graft-versus-host disease grades II–IV in ATG-treated patients (p = 0.0004 and p = 0.0002, respectively). Children with IL-7 levels comparable to healthy controls at day +14 post-HSCT were less likely to develop EBV reactivation posttransplant. These findings suggest that quantification of IL-7 and IL-15 may be useful as biomarkers in assessing the overall T cell depletion and suggest a potential for predicting complications after HSCT. |
| Databáze: | OpenAIRE |
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