Sleeve Gastrectomy for Obesity in Polycystic Ovarian Syndrome: a Pilot Study Evaluating Weight Loss and Fertility Outcomes
| Autor: | John Kuckelman, Cara Reitz, Matthew J. Martin, J Paul Sanders, Eric Ahnfeldt, Joshua Dilday, Michael Derickson |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Infertility
medicine.medical_specialty Sleeve gastrectomy endocrine system diseases Endocrinology Diabetes and Metabolism media_common.quotation_subject medicine.medical_treatment Population Patient characteristics Pilot Projects 030209 endocrinology & metabolism Fertility Gastroenterology 03 medical and health sciences 0302 clinical medicine Gastrectomy Weight loss Internal medicine Weight Loss medicine Humans Endocrine system education Retrospective Studies media_common education.field_of_study Nutrition and Dietetics business.industry medicine.disease Obesity female genital diseases and pregnancy complications Obesity Morbid Treatment Outcome Female 030211 gastroenterology & hepatology Surgery medicine.symptom business Polycystic Ovary Syndrome |
| Zdroj: | Obesity Surgery. 29:93-98 |
| ISSN: | 1708-0428 0960-8923 |
| DOI: | 10.1007/s11695-018-3473-8 |
| Popis: | Polycystic ovarian syndrome (PCOS) is a common endocrine disorder associated with obesity and infertility. Gastric bypass has been shown to be effective in treating these symptoms. However, the efficacy of vertical sleeve gastrectomy (VSG) has not been studied in the PCOS population. This study analyzed weight loss and fertility outcomes of VSG in this population. A retrospective review of patients with PCOS and without PCOS (CON) undergoing VSG from 2008 to 2016 was performed at two bariatric centers. BMI and percent excess weight loss (%EWL) were collected at 3, 6, and 12 months postoperatively. Patient characteristics and postoperative pregnancy status were compared between the two cohorts. One hundred nineteen PCOS patients were compared to 119 CON patients. Similar attrition rates were seen between cohorts at 3-month (5 vs 8%), 6-month (13 vs. 14%), and 12-month (18 vs. 13%) evaluation. PCOS patients had greater ΔBMI at 3 months (− 7.64 vs. − 6.82; p = 0.05), 6 months (− 10.56 vs. − 9.49; p = 0.02), and 12 months (− 12.43 vs. − 11.49; p = 0.04). PCOS patients also had greater %EWL at 12 months compared to CON (66 vs 60%; p = 0.05). Twenty-two percent of PCOS patients became pregnant within 12 months, 69% of which were previously nulliparous. Compared to non-PCOS patients, PCOS patients had greater postoperative ΔBMI and %EWL at 1 year. The majority of patients becoming pregnant after VSG were previously nulliparous. This study shows that VSG is effective for weight loss in PCOS patients with obesity and may positively augment effect fertility rates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink