Validation of fatty liver disease scoring systems for ultrasound diagnosed non-alcoholic fatty liver disease in adolescents
| Autor: | John K. Olynyk, Wendy H. Oddy, Therese A. O'Sullivan, Trevor A. Mori, Lawrence J. Beilin, Oyekoya T. Ayonrinde, Leon A. Adams, Fuzhen Wan, Feng Pan |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Adolescent Population Disease Gastroenterology Decision Support Techniques 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Internal medicine medicine Humans Suprailiac Skinfold Thickness education Ultrasonography education.field_of_study Hepatology business.industry Incidence (epidemiology) Fatty liver Ultrasound nutritional and metabolic diseases Non alcoholic medicine.disease Skinfold Thickness Cross-Sectional Studies 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Steatosis business Follow-Up Studies |
| Zdroj: | Digestive and Liver Disease. 53:746-752 |
| ISSN: | 1590-8658 |
| Popis: | Background and Aims The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing in young populations. However, there are inadequate data regarding diagnosis of NAFLD. We aimed to validate three scoring systems against a previous standard of suprailiac skinfold thickness for diagnosing NAFLD in population-based adolescents. Methods Seventeen-year-old adolescents (n = 899), participating in the Raine Study, attended a cross-sectional follow-up. NAFLD was diagnosed using liver ultrasound. Scores for Fatty liver index (FLI), Hepatic Steatosis Index (HSI) and Zhejiang University index (ZJU index) were calculated. Diagnostic accuracy of these diagnostic tests was evaluated through discrimination and calibration. Results NAFLD was diagnosed 9% in males and 15% in females. The three scoring systems demonstrated better discrimination performance for NAFLD in males (AUC was FLI:0.82, HSI: 0.83 and ZJU index: 0.83) compared to females (AUC was FLI: 0.67, HSI: 0.67 and ZJU index: 0.67). Suprailiac skinfold performed better than the scoring systems (overall AUC: 0.82; male AUC:0.88; female AUC:0.73). FLI had best calibration performance. Conclusion Suprailiac skinfold thickness was a better predictor of ultrasound-diagnosed NAFLD than the three diagnostic scoring systems investigated. The higher performance characteristics of the algorithmic scoring systems in males compared with females may have implications for use in population assessments. |
| Databáze: | OpenAIRE |
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