Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for EsxW Beijing variant in Vietnam
| Autor: | Nguyen Thuy Thuong Thuong, Nguyen Thi Quynh Nhu, Paul R. McAdam, Jeremy Farrar, David J. Edwards, Vu T. N. Ha, Kim Pham, Phan Vuong Khac Thai, Artika P. Nath, Kathryn E. Holt, Hoang Thanh Hai, Maxine Caws, Guy E. Thwaites, Nguyen Huu Lan, Nguyen Ngoc Lan, Yik Ying Teo, Dang Thi Minh Ha, Michael Inouye, Chiea Chuen Khor, David B. Ascher, Sarah J. Dunstan |
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| Přispěvatelé: | Holt, Kathryn E [0000-0003-3949-2471], Khor, Chiea Chuen [0000-0002-1128-4729], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
DNA Bacterial wa_4 Tuberculosis Lineage (genetic) Genotype Population qw_125 Biology wc_302 Polymorphism Single Nucleotide wf_205_1 Article Mycobacterium tuberculosis 03 medical and health sciences Beijing Genetics medicine Humans education education.field_of_study Transmission (medicine) respiratory system medicine.disease biology.organism_classification bacterial infections and mycoses Virology 3. Good health 030104 developmental biology Vietnam Microbial genetics |
| Zdroj: | Nature genetics |
| ISSN: | 1546-1718 1061-4036 |
| Popis: | To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere. The data identify an underlying burden of disease caused by the endemic Mtb lineage 1 associated with the activation of long-term latent infection, and a threefold higher burden associated with the more recently introduced Beijing lineage and lineage 4 Mtb strains. We find that Beijing lineage Mtb is frequently transferred between Vietnam and other countries, and detect higher levels of transmission of Beijing lineage strains within this host population than the endemic lineage 1 Mtb. Screening for parallel evolution of Beijing lineage-associated SNPs in other Mtb lineages as a signal of positive selection, we identify an alteration in the ESX-5 type VII-secreted protein EsxW, which could potentially contribute to the enhanced transmission of Beijing lineage Mtb in Vietnamese and other host populations. |
| Databáze: | OpenAIRE |
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