Clinical significance of high-mobility group box-1 (HMGB1) in subjects with type 2 diabetes mellitus (T2DM) combined with chronic obstructive pulmonary disease (COPD)

Autor: Yongjian Tian, Jianlin Yu, Jiayi Huang, Tingting Zeng, Zihuan Pei, Liming Tan, Yang Wu
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Vital capacity
endocrine system diseases
type 2 diabetes mellitus
Clinical Biochemistry
independent risk factor
Gastroenterology
chemistry.chemical_compound
Pulmonary Disease
Chronic Obstructive
0302 clinical medicine
Immunology and Allergy
HMGB1 Protein
Research Articles
COPD
Hematology
Middle Aged
Respiratory Function Tests
Medical Laboratory Technology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Regression Analysis
Female
Research Article
Microbiology (medical)
medicine.medical_specialty
chronic obstructive pulmonary disease
03 medical and health sciences
FEV1/FVC ratio
Internal medicine
White blood cell
medicine
Humans
Clinical significance
Risk factor
Aged
high‐mobility group box‐1
business.industry
Biochemistry (medical)
Public Health
Environmental and Occupational Health
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
medicine.disease
type 2 diabetes mellitus combined with chronic obstructive pulmonary disease
respiratory tract diseases
030104 developmental biology
chemistry
Diabetes Mellitus
Type 2
Case-Control Studies
Glycated hemoglobin
Insulin Resistance
business
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
Popis: Background Simple method to predict type 2 diabetes mellitus (T2DM) combined with chronic obstructive pulmonary disease (COPD) is in great need clinically. This study aims to assess the clinical significance of high‐mobility group box‐1 (HMGB1) in predicting T2DM combined with COPD in Chinese patients with T2DM or COPD. Methods Serum concentrations of glycated hemoglobin (HbA1C), fasting plasma glucose (FPG), fasting insulin (FINS), total cholesterol (TC), triglyceride (TG), low‐density lipoprotein cholesterol (LDL‐c), high‐density lipoprotein cholesterol (HDL‐c), C‐reactive protein (CRP), fibrinogen (FIB), HMGB1, white blood cell count (WBC), neutrophil% (NEU%), and lung function text such as forced expiratory volume 1/forced vital capacity (FEV1/FVC) and forced expiratory volume 1% predicted value (FEV1%pred) were measured in 126 T2DM patients, 118 COPD patients, 112 T2DM combined with COPD patients, and 120 healthy controls. Logistic regression was used to estimate the risk factors for T2DM combined with COPD. Results High‐mobility group box‐1 elevated in patients with T2DM combined with COPD, significantly higher than other subjects (P
Databáze: OpenAIRE
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