Immunohistochemical expression of tumor antigens MAGE-A1, MAGE-A3/4, and NY-ESO-1 in squamous cell carcinoma of the penis
| Autor: | Tvrtko Hudolin, Giulio C. Spagnoli, Antonio Juretić, Josip Pasini, Bozo Kruslin, Jordan Dimanovski, Davor Tomas, Michael Heberer |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Urology Antigens Neoplasm Testis Penile Carcinoma Carcinoma medicine Humans Penile Neoplasms Aged Aged 80 and over Melanoma-associated antigen business.industry CT antigens MAGE NE-ESO-1 penis cancer Membrane Proteins Middle Aged medicine.disease Immunohistochemistry Neoplasm Proteins medicine.anatomical_structure Epidermoid carcinoma Carcinoma Squamous Cell Cancer/testis antigens NY-ESO-1 business Melanoma-Specific Antigens Penis |
| Zdroj: | Urology. 68:205-207 |
| ISSN: | 0090-4295 |
| Popis: | Objectives To investigate by immunohistochemistry the expression of MAGE-A and NY-ESO-1/LAGE-1, cancer testis antigens (CTAs), in squamous cell carcinoma of the penis. Methods A total of 30 penile carcinoma samples from patients undergoing penile amputation at the Urology Clinics at the Zagreb Clinical Hospital Center and University Hospital “Sestre milosrdnice” from 1997 to 2004 were investigated in this study. Three monoclonal antibodies were used for immunohistochemical staining: 77B specific for MAGE-A1, 57B recognizing multiple MAGE-A CTAs, and D8.38, specific for NY-ESO-1 antigen. Results The expression of MAGE-A1 was not observed in the carcinoma samples, but both multi-MAGE-A and NY-ESO-1-specific reagents stained 29 (97%) of 30 samples. Immunohistochemical staining was prevailingly detected in the cytoplasm. A significant heterogeneity was observed within the same specimen, in which areas with strong positivity coexisted with CTA-negative areas. The extent of CTA expression did not correlate significantly with tumor grade. Conclusions The results of this study have documented for the first time the expression of CTAs in squamous cell carcinoma of the penis. Additional research is warranted to explore the potential implications regarding both diagnosis and therapy. |
| Databáze: | OpenAIRE |
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