Fosfadecin and fosfocytocin, new nucleotide antibiotics produced by bacteria
| Autor: | Hideo Ono, Nozomi Katayama, Yukimasa Nozaki, Setsuo Harada, Shigetoshi Tsubotani |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Magnetic Resonance Spectroscopy
medicine.drug_class Antibiotics Pseudomonas fluorescens Biology Fosfomycin Cytidine Diphosphate Microbiology Mice Pseudomonas Drug Discovery medicine Cytidine Monophosphate Animals Escherichia coli Infections Antibacterial agent Pharmacology Chromatography Bacteria Molecular Structure Pseudomonas viridiflava Hydrolysis Staphylococcal Infections biology.organism_classification Anti-Bacterial Agents Adenosine Diphosphate Pseudomonadales Fermentation Antibacterial activity medicine.drug |
| Zdroj: | The Journal of antibiotics. 43(3) |
| ISSN: | 0021-8820 |
| Popis: | Two new nucleotide antibiotics, fosfadecin and fosfocytocin, have been isolated from the culture filtrates of Pseudomonas viridiflava PK-5 and Pseudomonas fluorescens PK-52, respectively. These antibiotics were purified by column chromatographies using adsorption, gel filtration and ion exchange resins. On the basis of the spectroscopic and degradation studies, the chemical structures of fosfadecin and fosfocytocin were determined. These antibiotics were either enzymatically or chemically hydrolyzed to generate fosfomycin and a new antibiotic, fosfoxacin, which are also produced in the culture filtrates. They showed antibacterial activity against Gram-positive and Gram-negative bacteria. The antibacterial activity of these nucleotide antibiotics was weaker than that of fosfomycin and fosfoxacin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|