Screening Sensitivity According to Breast Cancer Location
| Autor: | Marie-Hélène Guertin, Isabelle Théberge, Éric Pelletier, Nathalie Vandal, Michel-Pierre Dufresne, Jacques Brisson, Gary Côté |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Breast Neoplasms Logistic regression Sensitivity and Specificity Body Mass Index 030218 nuclear medicine & medical imaging 03 medical and health sciences Breast cancer screening 0302 clinical medicine Breast cancer Humans Medicine Mammography Radiology Nuclear Medicine and imaging Breast 030212 general & internal medicine Aged Breast Density medicine.diagnostic_test business.industry Obstetrics Cancer General Medicine Middle Aged medicine.disease Confidence interval Female business Body mass index Sensitivity (electronics) |
| Zdroj: | Canadian Association of Radiologists Journal. 70:186-192 |
| ISSN: | 1488-2361 0846-5371 |
| Popis: | Purpose To examine the relation between breast cancer location and screening mammogram sensitivity, and assess whether this association is modified by body mass index (BMI) or breast density. Methods This study is based on all interval cancers (n = 481) and a random sample of screen-detected cancers (n = 481) diagnosed in Quebec Breast Cancer Screening Program participants in 2007. Film-screening mammograms, diagnostic mammograms, and ultrasound reports (when available) were requested for these cases. The breast cancer was then localised in mediolateral oblique (MLO) and craniocaudal (CC) projections of the breast by 1 experienced radiologist. The association between cancer location and screening sensitivity was assessed by logistic regression. Adjusted sensitivity and sensitivity ratios were obtained by marginal standardisation. Results A total of 369 screen-detected and 268 interval cancers could be localised in MLO and/or CC projections. The 2-year sensitivity reached 68%. Overall, sensitivity was not statistically associated with location of the cancer. However, sensitivity seems lower in MLO posterior inferior area for women with BMI ≥ 25 kg/m2 compared to sensitivity in central area for women with lower BMI (adjusted sensitivity ratio: 0.58, 95% confidence interval [CI]: 0.17–0.98). Lower sensitivity was also observed in subareolar areas for women with breast density ≥ 50% compared to the central areas for women with lower breast density (for MLO and CC projections, adjusted sensitivity ratio and 95% CI of, respectively, 0.54 [0.13–0.96] and 0.46 [0.01–0.93]). Conclusions Screening sensitivity seems lower in MLO posterior inferior area in women with higher BMI and in subareolar areas in women with higher breast density. When interpreting screening mammograms, radiologists need to pay special attention to these areas. |
| Databáze: | OpenAIRE |
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