Heat shock response and insulin-associated neurodegeneration
| Autor: | Michael Joseph Urban, Brian S. J. Blagg, Rick T. Dobrowsky |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
Growth factor medicine.medical_treatment Insulin Neurodegeneration Neurodegenerative Diseases Biology Protein aggregation Toxicology medicine.disease Bioinformatics Article Peripheral neuropathy Diabetes mellitus Heat shock protein Immunology medicine Animals Humans Heat shock Insulin-Like Growth Factor I Heat-Shock Proteins Heat-Shock Response |
| Popis: | Dysfunctional insulin and insulin-like growth factor-I (IGF-I) signaling contributes to the pathological progression of diabetes, diabetic peripheral neuropathy (DPN), Alzheimer's (AD), Parkinson's (PD) and Huntington's diseases (HD). Despite their prevalence, there are limited therapeutic options available for the treatment of these neurodegenerative disorders. Therefore, establishing a link between insulin/IGF-I and the pathoetiology of these diseases may provide alternative approaches toward their management. Many of the heat shock proteins (Hsps) are well-known molecular chaperones that solubilize and clear damaged proteins and protein aggregates. Recent studies suggest that modulating Hsps may represent a promising therapeutic avenue for improving insulin and IGF-I signaling. Pharmacological induction of the heat shock response (HSR) may intersect with insulin/IGF-I signaling to improve aspects of neurodegenerative phenotypes. Herein, we review the intersection between Hsps and the insulin/IGF systems under normal and pathological conditions. The discussion will emphasize the potential of non-toxic HSR inducers as viable therapeutic agents. |
| Databáze: | OpenAIRE |
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