REGULARITIES OF CARDIOMYOGENESIS IN WISTAR RATS: CARDIOMYOCYTES NUMBER OF GROWTH AND FORMATION OF PUBLICATION OF DUAL MYOCYTES IN THE COMPLEX MYOCARDIUM (LV + IVF)
| Autor: | V. P. Martsinovsky, V. Filatova, G. E Zagoruуko, Yu. V. Zagoruуko |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Вісник проблем біології і медицини, Vol 2, Iss 1, Pp 70--5 (2019) |
| ISSN: | 2523-4110 2077-4214 |
| DOI: | 10.29254/2077-4214-2019-1-2-149-70-75 |
| Popis: | In the work were used: 15-16 and 20-21 daily embryos of rats, newborns, 1 45 daily rats Wistar males. A morphometric analysis of the myocardial parenchyma of the complex left ventricle + interventricular septum (LV + IVF) was performed. It was established that in the process of prenatal and postnatal cardiomyogenesis (15 days before and 45 days after) birth, the total number of CMC (? cmc = N1-ñ 1st cmc + N2-ñ cmc) in the parenchyma (LV + IVF) increases by 4,34 times (from 0.35 to 1.52) x 107 cmc. During the period of embryonic cardiomyogenesis (15-21) days, the values of L cmc increase by 2 times (from 0.35 to 0.74) x 107 cmc. In the process of postnatal cardiomyogenesis, in the time interval (newborns 15 daily rats), the volume of values cmc also increases by 2 times (from 0.77 to 1.52) x 107 cmc. In the time interval (1545) days, the total number of cmc does not change ? cmc ? const ? (1.51 ± 0.02) x 107 cmc. During the embryonic period of cardiomyogenesis continuous proliferation of cmc occurs with a maximum speed of 3.75 x 104 cmc/h or 625 cmc/min in the myocardial parenchyma of the newborn rat pups. After birth a significant decrease in the rate of proliferative processes in the myocardial parenchyma is observed. at t > 15 days, ?N cmc/day > 0. The formation of the 2nd cmc population in the myocardium of the complex (LV + IVF) begins from the 19th day of embryogenesis in rats. In the process of cardiomyogenesis (18 days before and 15 days after) the birth of rat pups as a result of polyploidy the number of 2nd cmc in the parenchyma (LV + IVF) increases 1000 times! (from 0.00144 to 1.44) x 107 cmc. In the time interval tº (15 45) days the digital values of the index N 2cmc ? const ? 1.44 x 107 cmc. Therefore, after the completion of the postnatal period of cardiomyogenesis, the number of 2nd cmc does not change and amounts to ? 94 95% of the total number of myocytes in the myocardial parenchyma of the complex (LV + IVF). The most active polyploidy process of cmc occurs within 5 days after the birth of rat pups. The maximum speed of polyploidy of cmc is determined on the 5th day and is equal to 73 x 103 cmc/h or 1215 cmc/min. |
| Databáze: | OpenAIRE |
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