Phenoxydifluoromethyl Substituted Nitrogen Heterocycles. Synthesis and Heterocyclization Reactions of Ethyl 4,4-Difluoro- 4-phenoxyacetoacetate

Autor: Chkanikov Nd, Vorontsov Ev, Peregudov As, Solodukhin Sy
Rok vydání: 2004
Předmět:
Zdroj: Molecules, Vol 9, Iss 3, Pp 164-169 (2004)
Molecules; Volume 9; Issue 3; Pages: 164-169
ISSN: 1420-3049
DOI: 10.3390/90300164
Popis: Ethyl 4,4-difluoro-4-phenoxyacetoacetate was obtained and studied as a precursor to new heterocyclic compounds. 6-Hydroxypyrimidine, 1,3-dihydro-1,5- benzodiazepin-2-one, quinolin-2-one and 6-hydroxypyrazolo[3,4-b]pyridine derivatives containing phenoxydifluoromethyl groups were synthesized. These results make it possible to introduce aryloxydifluoromethyl substituents for the design of biologically active heterocycles.
Databáze: OpenAIRE