Hypercalcemia caused by humoral effects and bone damage indicate poor outcomes in newly diagnosed multiple myeloma patients

Autor: Lijuan Fang, Minqiu Lu, Bin Chu, Qiuqing Xiang, Li Bao, Lei Shi, Shan Gao, Yutong Wang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Adult
Male
Cancer Research
medicine.medical_specialty
Time Factors
Databases
Factual
Parathyroid hormone
Osteolysis
Malignancy
Gastroenterology
Risk Assessment
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
N-terminal telopeptide
Risk Factors
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
parathyroid hormone
Humans
Radiology
Nuclear Medicine and imaging
Multiple myeloma
Original Research
Aged
Retrospective Studies
Aged
80 and over
Creatinine
Univariate analysis
Beta-2 microglobulin
business.industry
Clinical Cancer Research
hypercalcemia
Middle Aged
medicine.disease
Prognosis
multiple myeloma
030104 developmental biology
Oncology
chemistry
030220 oncology & carcinogenesis
Uric acid
Calcium
Female
business
Biomarkers
Zdroj: Cancer Medicine
ISSN: 2045-7634
Popis: Background Hypercalcemia of malignancy (HCM) is a serious metabolic complication, and the highest rates are in multiple myeloma (MM). The cause of hypercalcemia in newly diagnosed multiple myeloma (NDMM) remains unknown. We sought to evaluate the prognostic impact and mechanism of hypercalcemia in patients with symptomatic NDMM. Methods We studied all consecutive MM patients who were initially diagnosed and followed up at Beijing Jishuitan Hospital between February 2013 and December 2019; 357 patients were included in the retrospective analysis. Results A total of 16.8% of MM patients presented with hypercalcemia at the time of MM diagnosis. The presence of hypercalcemia was associated with higher serum levels of β2 microglobulin, creatinine, phosphorus, uric acid, procollagen I N‐terminal peptide, β‐carboxy‐terminal cross‐linking telopeptide of type I collagen and osteocalcin, lower serum levels of hemoglobin, parathyroid hormone (PTH), and advanced ISS and R‐ISS stages. Multivariate analysis showed that serum PTH, hemoglobin, creatinine, and uric acid levels were the main factors affecting hypercalcemia. The presence of hypercalcemia was associated with significantly inferior survival (40 months vs 57 months, p
This study has shown that hypercalcemia is associated with poor survival and is caused by manifold factors with humoral effects and local bone destruction.
Databáze: OpenAIRE
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