Effects of MgCl2 supplementation on blood parameters and kidney injury of rats exposed to CCl4
| Autor: | Sabah Dhibi, Sakhria Mbarki, Najla Hfaiedh, Hafsia Bouzenna, Abdelfettah Elfeki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty kidney QH301-705.5 CCL4 Biology magnesium medicine.disease_cause digestive system General Biochemistry Genetics and Molecular Biology Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Internal medicine medicine oxidative stress Biology (General) chemistry.chemical_classification Kidney Hematology General Immunology and Microbiology hematology General Neuroscience Glutathione peroxidase ccl4 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Toxicity Uric acid General Agricultural and Biological Sciences Oxidative stress |
| Zdroj: | Open Life Sciences, Vol 11, Iss 1, Pp 250-258 (2016) |
| ISSN: | 2391-5412 |
| Popis: | The purpose of this study was to evaluate the beneficial effects of magnesium (Mg) supplementation upon carbon tetrachloride (CCl4) toxicity. Our study was carried out on 24 Wistar male rats divided into 4 batches. During a 6 week period, one group served as a control, two groups received Mg (after 4 weeks one of these groups was then treated with CCl4), and a final group was treated with CCl4 only. Under our experimental conditions, CCl4 poisoning resulted in oxidative stress indicated by a significant increase in lipid peroxidation level in renal tissues. The blood levels of creatinine and urea increased while the blood level of uric acid and proteins decreased. CCl4 also induced an increase in superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity in kidneys, in the number of red blood cells (RBC), and in hemoglobin content (Hb) and mean cell hemoglobin concentration (MCHC). However, white blood cell count (WBC), platelet count (Pl) and catalase activity (CAT) all decreased significantly. Treatment with Mg was found to alleviate most of CCl4-induced damage by decreasing lipid peroxidation and by correcting changed hematological parameters, and catalase, glutathione peroxidase and superoxide-dismutase activities. The results provide strong evidence that Mg supplementation is beneficial in protecting the kidneys from CCl4 toxicity. |
| Databáze: | OpenAIRE |
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