Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats
| Autor: | Katarzyna Matusiak, Zuzanna Setkowicz, Agnieszka Drozdz, Marzena Rugiel, Krzysztof Klodowski, Joanna Chwiej |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Elemental analysis Endocrinology Diabetes and Metabolism Clinical Biochemistry total reflection X-ray fluorescence microscopy 02 engineering and technology Cluster and discriminant analysis Biochemistry Article Inorganic Chemistry Total reflection X-ray fluorescence microscopy 03 medical and health sciences chemistry.chemical_compound Iron oxide nanoparticles Male rats multivariate methods Animals 030304 developmental biology 0303 health sciences cluster and discriminant analysis Biochemistry (medical) iron oxide nanoparticles elemental analysis Metallome General Medicine 021001 nanoscience & nanotechnology Rats chemistry Liver Nanoparticles Multivariate methods Magnetic Iron Oxide Nanoparticles 0210 nano-technology Biomarkers |
| Zdroj: | Biological Trace Element Research |
| ISSN: | 1559-0720 |
| Popis: | The systemic influence of iron oxide nanoparticles on the elemental homeostasis of key organs was examined in male rats. In tissues taken at different intervals from nanoparticles injection, the dynamics of elemental changes was analyzed. The organ metallome was studied using total reflection X-ray fluorescence. The obtained data were processed with advanced cluster and discriminant analyses—to classify the tissues according to their organs of origin and to distinguish accurately the nanoparticle-treated and normal rats. Additionally, in the case of liver and heart, it was possible to determine the elements of highest significance for different treatments, which may serve as markers of exposure to iron oxide nanoparticles. Electronic supplementary material The online version of this article (10.1007/s12011-020-02104-z) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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