Anti-inflammatory effects of Artemisia stechmanniana Besser extract on LPS-stimulated macrophages
| Autor: | Ganbold Enebish, Hyun Jun Jang, Chi Hwan Jeong, Wan-Hoon Kim, Soo-Yong Kim, Jisu Kim, Hyeyoung Min |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
mitogen-activated protein kinase
medicine.drug_class Agriculture (General) Immunology Central asia Inflammation macrophage Biology Nuclear factor kappa b Anti-inflammatory S1-972 parasitic diseases medicine Macrophage anti-inflammatory Folk medicine artemisia Traditional medicine food and beverages RC581-607 biology.organism_classification Mitogen-activated protein kinase nuclear factor kappa-b biology.protein population characteristics Artemisia medicine.symptom Immunologic diseases. Allergy Agronomy and Crop Science geographic locations Food Science |
| Zdroj: | Food and Agricultural Immunology, Vol 32, Iss 1, Pp 679-692 (2021) |
| ISSN: | 1465-3443 0954-0105 |
| Popis: | A. stechmanniana Besser is a semi-shrub plant indigenous to Mongolia, Central Asia, Russia, and Pakistan. Although A. stechmanniana has been used as folk medicine for inflammation, helminth infection, and tumors, the physiological activities of A. stechmanniana have not been fully experimentally validated. We investigated the anti-inflammatory activities and underlying mechanisms of action of A. stechmanniana on LPS-stimulated murine macrophages. Macrophages treated with A. stechmanniana-methanol extract (As-ME) showed the decreased expression of inducible NO synthase and cyclooxygenase-2 and secretion of NO, prostaglandin E2, and pro-inflammatory cytokines. Furthermore, we found As-ME reduced the phosphorylation of c-Jun N-terminal kinase (JNK), which was accompanied by a decrease in c-Jun in the nucleus, and suppressed the phosphorylation of NF-��B inhibitor �� and the translocation of NF-��B into the nucleus. The results indicated that As-ME possesses anti-inflammatory effects mediated through inhibition of JNK and NF-��B phosphorylation. |
| Databáze: | OpenAIRE |
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