Folic Acid-Conjugated pH and Redox-Sensitive Ellipsoidal Hybrid Magnetic Nanoparticles for Dual-Triggered Drug Release
| Autor: | Gökçen Birlik Demirel, Zeynep Cimen, Ebru Aygul, Sezen Atasoy, Busra Cetin, Aydan Dağ |
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| Přispěvatelé: | DAĞ, AYDAN |
| Rok vydání: | 2020 |
| Předmět: |
Birlik Demirel G.
Aygul E. DAĞ A. ATASOY S. Cimen Z. Cetin B. -Folic Acid-Conjugated pH and Redox-Sensitive Ellipsoidal Hybrid Magnetic Nanoparticles for Dual-Triggered Drug Release- ACS Applied Bio Materials cilt.3 ss.4949-4961 2020 Chemistry Biochemistry (medical) Multifunctional nanoparticles technology industry and agriculture Biomedical Engineering Nanotechnology General Chemistry Conjugated system Redox sensitive Biomaterials Targeted drug delivery Folic acid Drug delivery Drug release Magnetic nanoparticles |
| Zdroj: | ACS Applied Bio Materials. 3:4949-4961 |
| ISSN: | 2576-6422 |
| DOI: | 10.1021/acsabm.0c00488 |
| Popis: | © 2020 American Chemical Society.Stimuli-sensitive and multifunctional nanoparticles are highly desirable biomedical materials for triggered and targeted drug delivery applications. Here, we have designed pH- A nd redox-triggered magnetic lipid-polymer hybrid nanoparticles (MHNPs) with a core-shell structure. This design is composed of a silica-/mesoporous silica-coated ellipsoidal magnetic nanoparticle with multifunctionality: Carrying the anticancer drug (doxorubicin, DOX), the cancer cell targeting ligand (folic acid-conjugated poly(ethylene glycol), FA-PEG) polymer, and being coated with a biocompatible pH-/redox-responsive (poly-l-histidine-poly(ethylene glycol)-lipoic acid; PLH-PEG-LA) polymer. The lipoic acid units of the PLH-PEG-LA shell of the FA-MHNPs were cross-linked using 1,4-dithiothreitol (DTT). When the FA-MHNPs-DOX were exposed to an endolysosomal pH of 5.5 and 10 mM glutathione (GSH), the particles exhibited a very efficient DOX release profile within 24 h. In addition, cytotoxicity, uptake, and apoptosis assays were performed against breast cancer cell lines. These results showed that FA-MHNPs-DOX promote an enhanced uptake and cell morbidity compared to the nontargeted MHNPs-DOX against tested cell lines. Moreover, the FA-MHNPs-DOX exhibited very effective cytotoxicity and also decreased the cell viability through apoptosis against breast cancer cell lines. In conclusion, it can be said that the pH and redox dual-responsive hybrid FA-MHNPs-DOX has a great potential for controlled drug release. Türkiye Bilimsel Ve Teknolojik Araştırma Kurumu ( Tübitak ) |
| Databáze: | OpenAIRE |
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